Carmofur (Standard)
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98%
- No. CAS: 61422-45-5
- Fòrmula: C11H16FN3O3
- Peso molecular:257.26
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 61422-45-5
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Peso molecular 257.26
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Fòrmula C11H16FN3O3
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SMILES
O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
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Synonyms
HCFU (Standard)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Jin Z, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 Jun;27(6):529-532. [Content Brief]
[2]. Realini N, Solorzano C, Pagliuca C, et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity[J]. Scientific reports, 2013, 3(1): 1035. [Content Brief]
[3]. Wu K, et al. A new use for an old drug: carmofur attenuates lipopolysaccharide (LPS)-induced acute lung injury via inhibition of FAAH and NAAA activities[J]. Frontiers in pharmacology, 2019, 10: 818. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carmofur (Standard) Related Classifications
HY-B0182R Related Classifications
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- Carmofur (Standard)
- 61422-45-5
- HCFU (Standard)
- Reference Standards
- Nucleoside Antimetabolite/Analog
- SARS-CoV
- Virus Protease
- FAAH
- Ceramidase
- Glutathione Peroxidase
- Inflammation
- rectal cancer
- tumor
- anti-cancer
- anti-inflammatory
- COVID-19
- SARS-CoV-2
- acute lung injury (ALI)
- SW403
- Vero E6
- HEK293
- Raw264.7
- Swiss Webster
- C57BL/6J
- Inhibitor
- inhibitor
- inhibit