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Referencia número: HY-117852

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CGP-59326

(Synonyms: TRX-13)

CGP-59326 (TRX-13) is a highly potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC₅₀=0.027 μM). CGP-59326 blocks the EGFR signaling pathwa, demonstrating highly selective inhibition of EGFR-dependent tumor cells. CGP-59326 is promising for research of cancers.

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No. CAS: 173458-56-5
Fòrmula: C₁₄H₁₃ClN₄
Peso molecular:272.73

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CGP-59326 Chemical Structure

No. CAS: 173458-56-5

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

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Descripciòn

Ver todos los productos específicos de isoformas EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	1.5 mg/kg Compound: 13	In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R	[PMID: 8691423]
A-431	IC₅₀	0.3 μM Compound: 13	Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R	[PMID: 8691423]
Balb/MK	IC₅₀	1.4 μM Compound: 13	Inhibition of proliferation of EGF-dependent BALB/MK cells Inhibition of proliferation of EGF-dependent BALB/MK cells	[PMID: 8691423]
NIH3T3	IC₅₀	>10 μM Compound: 13	Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	2 μM Compound: 13	Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]

Chemical Information

No. CAS 173458-56-5
Peso molecular 272.73
Fòrmula C₁₄H₁₃ClN₄
SMILES

ClC1=CC=CC(NC2=NC=NC3=C2C(C)=C(C)N3)=C1
Synonyms

TRX-13
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Traxler P, et al. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol Ther. 1999 May-Jun;82(2-3):195-206. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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CGP-59326

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CGP-59326 Related Classifications

HY-117852 Related Classifications