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Crotoniazide

Crotoniazide (compound 9) is an isonicotinic acid hydrazide derivative with anti-HIV potential with an EC₅₀ value of 11 ug/mL.

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No. CAS: 7007-96-7
Fòrmula: C₁₀H₁₁N₃O
Peso molecular:189.21

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Crotoniazide Chemical Structure

No. CAS: 7007-96-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Crotoniazide (compound 9) is an isonicotinic acid hydrazide derivative with anti-HIV potential with an EC₅₀ value of 11 ug/mL^[1].

IC₅₀ & Target

HIV-1

11 μg/mL (EC₅₀)

HIV-2 (ROD)

11 μg/mL (EC₅₀)

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HEL	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
HeLa	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
MT4	CC₅₀	11 μg/mL Compound: 9	Cytotoxicity against Homo sapiens (human) MT4 cells Cytotoxicity against Homo sapiens (human) MT4 cells	10.1007/s00044-011-9662-9
MT4	EC₅₀	>11 μg/mL Compound: 9	Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
MT4	EC₅₀	>11 μg/mL Compound: 9	Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9
Vero	EC₅₀	>20 μg/mL Compound: 9	Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity	10.1007/s00044-011-9662-9

Chemical Information

No. CAS 7007-96-7
Peso molecular 189.21
Fòrmula C₁₀H₁₁N₃O
SMILES

O=C(C1=CC=NC=C1)N/N=C/C=C/C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Vikramjeet Judge, et al. Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies. Medicinal Chemistry Research. 2012, 21.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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Crotoniazide

Ver todos los productos específicos de isoformas HIV