DMG-PEG3400-pPB

DMG-PEG3400-pPB is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against PDGFRβ on the surface of activated hepatic stellate cells, pericytes, and tumor-associated fibroblasts.
Composition and role of each component:
1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake.
2. PEG3400 (polyethylene glycol, MW 3400): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
3. pPB (platelet-derived growth factor receptor β-binding peptide (pPB)): Targeting ligand-a peptide that specifically recognizes and binds to platelet-derived growth factor receptor beta (PDGFRβ), which is highly expressed on activated hepatic stellate cells (HSCs), pericytes, and tumor-associated fibroblasts. Enables targeted delivery to fibrotic tissues and tumor stroma.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.