(E/Z)-3PO
Based on 1 Customer Validation
(E/Z)-3PO is a potent PFKFB3 inhibitor. (E/Z)-3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z)-3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.86%
- No. CAS: 13309-08-5
- Fòrmula: C13H10N2O
- Peso molecular:210.24
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Glycolysis Compound Library
HY-L058
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Phosphatase Inhibitor Library
HY-L081
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Anti-Cancer Metabolism Compound Library
HY-L083
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Glucose Metabolism Compound Library
HY-L092
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Anti-Pulmonary Fibrosis Compound Library
HY-L125
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Metabolic Enzyme Compound Library
HY-L146
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Epithelial cell | IC50 |
1.4 μM
Compound: 1; 3PO
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Cytotoxicity against human Epithelial cell assessed as cell growth inhibition
Cytotoxicity against human Epithelial cell assessed as cell growth inhibition
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[PMID: 32679452] |
Chemical Information
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No. CAS 13309-08-5
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Appearance Solid
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Peso molecular 210.24
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Fòrmula C13H10N2O
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=NC=C1)/C=C/C2=CC=CN=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 41.67 mg/mL (198.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7565 mL | 23.7823 mL | 47.5647 mL | 118.9117 mL |
| 5 mM | 0.9513 mL | 4.7565 mL | 9.5129 mL | 23.7823 mL | |
| 10 mM | 0.4756 mL | 2.3782 mL | 4.7565 mL | 11.8912 mL | |
| 15 mM | 0.3171 mL | 1.5855 mL | 3.1710 mL | 7.9274 mL | |
| 20 mM | 0.2378 mL | 1.1891 mL | 2.3782 mL | 5.9456 mL | |
| 25 mM | 0.1903 mL | 0.9513 mL | 1.9026 mL | 4.7565 mL | |
| 30 mM | 0.1585 mL | 0.7927 mL | 1.5855 mL | 3.9637 mL | |
| 40 mM | 0.1189 mL | 0.5946 mL | 1.1891 mL | 2.9728 mL | |
| 50 mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 2.3782 mL | |
| 60 mM | 0.0793 mL | 0.3964 mL | 0.7927 mL | 1.9819 mL | |
| 80 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4864 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1891 mL |
(E/Z)-3PO Related Classifications
HY-110169 Related Classifications
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