Fenpropidin
Based on 1 Customer Validation
Fenpropidin, a piperidine, is a fungicide used to control a range of diseases in cereals. Fenpropidin shows antifungal activity against different human pathogenic yeasts and filamentous fungi.
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- Pureza: 99.48%
- No. CAS: 67306-00-7
- Fòrmula: C19H31N
- Peso molecular:273.46
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Antifungal Compound Library
HY-L048
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Human Metabolite Library
HY-L123
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Heterocyclic Compound Library
HY-L138
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HY-L181
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MCE Bioactive Compound Library
HY-L001V
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HY-L001
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Pesticide Compound Library
HY-L183
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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HY-L247
Actividad biológica
Fenpropidin exhibits potent antifungal activity against Candida albicans ATCC 24433, C. albicans ATCC 10231, Candida glabrata NCYC 388, Candida tropicalis ATCC 750, Cryptococcus neoformans ATCC 34664, and Aspergillus niger ATCC 10578, with MIC values of 0.25 μg/mL, 1 μg/mL, 0.5 μg/mL, 4 μg/mL, 1 μg/mL, and 32 μg/mL, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 67306-00-7
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Appearance Liquid (Density: 0.9112 g/cm3)
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Peso molecular 273.46
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Fòrmula C19H31N
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Color Colorless to light yellow
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SMILES
CC(CN1CCCCC1)CC2=CC=C(C=C2)C(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 100 mg/mL (365.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (9.14 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.14 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (925 KB)
- English - EN (925 KB)
- Français - FR (925 KB)
- Deutsch - DE (925 KB)
- Norwegian - NO (925 KB)
- Español - ES (925 KB)
- Swedish - SV (925 KB)
- Italian - IT (925 KB)
- Korean - KR (925 KB)
- Portuguese - PT (925 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ignaz J Buerge, et al. Stereoselective Metabolism of the Sterol Biosynthesis Inhibitor Fungicides Fenpropidin, Fenpropimorph, and Spiroxamine in Grapes, Sugar Beets, and Wheat. J Agric Food Chem. 2016 Jul 6;64(26):5301-9. [Content Brief]
[2]. Jachak GR, et al. Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation. ACS Med Chem Lett. 2015 Sep 22;6(11):1111-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6568 mL | 18.2842 mL | 36.5684 mL | 91.4211 mL |
| 5 mM | 0.7314 mL | 3.6568 mL | 7.3137 mL | 18.2842 mL | |
| 10 mM | 0.3657 mL | 1.8284 mL | 3.6568 mL | 9.1421 mL | |
| 15 mM | 0.2438 mL | 1.2189 mL | 2.4379 mL | 6.0947 mL | |
| 20 mM | 0.1828 mL | 0.9142 mL | 1.8284 mL | 4.5711 mL | |
| 25 mM | 0.1463 mL | 0.7314 mL | 1.4627 mL | 3.6568 mL | |
| 30 mM | 0.1219 mL | 0.6095 mL | 1.2189 mL | 3.0474 mL | |
| 40 mM | 0.0914 mL | 0.4571 mL | 0.9142 mL | 2.2855 mL | |
| 50 mM | 0.0731 mL | 0.3657 mL | 0.7314 mL | 1.8284 mL | |
| 60 mM | 0.0609 mL | 0.3047 mL | 0.6095 mL | 1.5237 mL | |
| 80 mM | 0.0457 mL | 0.2286 mL | 0.4571 mL | 1.1428 mL | |
| 100 mM | 0.0366 mL | 0.1828 mL | 0.3657 mL | 0.9142 mL |
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