KL-1156
BMS-358233 (compound 3) is a Lck inhibitor (IC50: 1 nM; Ki: 540 pM) and inhibits T cell proliferation (IC50: 262 nM).
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- No. CAS: 819868-62-7
- Fòrmula: C17H17NO4
- Peso molecular:299.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 1 nM (Lck)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H23 | GI50 |
9.316 μM
Compound: KL-1156
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Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human NCI-H23 cells assessed as growth inhibition after 72 hrs by SRB assay
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[PMID: 24792464] |
| NCI-H23 | GI50 |
9.316 μM
Compound: KL-1156
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Cytotoxicity against human NCI-H23 cells
Cytotoxicity against human NCI-H23 cells
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[PMID: 20579876] |
| RAW264.7 | IC50 |
37.2 μM
Compound: KL-1156
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Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay
Inhibition of NF-kappaB (unknown origin) transcriptional activity in LPS-induced mouse RAW264.7 cells after 1 hr by secreted alkaline phosphatase assay
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[PMID: 25953156] |
| RAW264.7 | IC50 |
40.1 μM
Compound: KL-1156
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Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay
Inhibition of transcriptional activity of NF-kappaB (unknown origin) transfected in LPS-stimulated mouse RAW264.7 cells after 16 hrs by secretory alkaline phosphatase reporter gene assay
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[PMID: 24792464] |
| RAW264.7 | IC50 |
40.1 μM
Compound: KL-1156
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Inhibition of LPS-induced NF-kappaB transcriptional activity in mouse RAW264.7 cells
Inhibition of LPS-induced NF-kappaB transcriptional activity in mouse RAW264.7 cells
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[PMID: 20579876] |
| RAW264.7 | IC50 |
53 μM
Compound: KL-1156
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Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
Inhibition of LPS-induced NFkappaB (unknown origin) transcriptional activity expressed in mouse RAW264.7 cells incubated for 16 hrs by SEAP based reporter gene assay
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[PMID: 27096046] |
Chemical Information
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No. CAS 819868-62-7
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Peso molecular 299.32
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Fòrmula C17H17NO4
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SMILES
O=C(NC1=CC=CC=C1)C2CCC3=C(C=C(C(O)=C3)OC)O2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KL-1156 Related Classifications
HY-121849 Related Classifications
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