Referencia número: HY-N3121

Pachypodol

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer.

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Pureza: 99.82%
No. CAS: 33708-72-4
Fòrmula: C₁₈H₁₆O₇
Peso molecular:344.32

Almacenamiento:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Pachypodol Chemical Structure

No. CAS: 33708-72-4

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	>47.8 μM Compound: 7	Cytotoxicity against human KB cells by sulforhodamine B assay Cytotoxicity against human KB cells by sulforhodamine B assay	[PMID: 26928423]
NCI-H460	IC₅₀	17.2 μM Compound: 10	Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C	[PMID: 21275386]
Neutrophil	IC₅₀	0.99 μg/mL Compound: 11	Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release	[PMID: 18163582]
Neutrophil	IC₅₀	1 μg/mL Compound: 11	Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation	[PMID: 18163582]
Vero	IC₅₀	>47.8 μM Compound: 7	Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay	[PMID: 26928423]

In Vitro

Pachypodol (3-30 μM; 1-12 h) significantly prevents oxidative stress-induced cell death in HepG2 cells in a concentration-dependent manner^[1].
Pachypodol (0-30 μM; 24 h) inhibits the growth of CaCo-2 colon cancer cell line, with an IC₅₀ value of 185.6 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

30 μM
Incubation Time:

10 min, 30 min, 1 h, 3 h, 6 h, 12 h, 24 h
Result:

Upregulated the protein levels of Nrf2-controlled antioxidant genes such as GCLC and NQO1.
Increased ERK phosphorylation.

In Vivo

Pachypodol (10 mg/kg; 30 days) attenuates Arsenic triggered cardiac damage in rats via rectifying oxidative stress, inflammation, apoptosis and histopathological alterations^[3].
Pachypodol (10-30 mg/kg; i.v.; 30 min before isoflurane exposure) reduces neuronal apoptosis and oxidative stress in Isoflurane (HY-A0134)-induced neuron-injured rats by regulating the JNK/ERK pathway, and also ameliorates cognitive function and neurological scores^[4].
Pachypodol (20 mg/kg; p.o.; once a day; 7-28 days) significantly alleviates Cisplatin (HY-17394)-induced hepatic impairment in albino rats by inhibiting oxidative stress, inflammation, and apoptosis, and mitigates histopathological liver damage^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Seven-day-old Sprague-Dawley rat pups (15-18 g), Isoflurane (HY-A0134)-induced neuronal injury model in developing brain^[4]
Dosage:

10 mg/kg, 30 mg/kg
Administration:

Intravenous injection, once (30 min before Isoflurane exposure)
Result:

Reduced the levels of inflammatory mediators such as TNF-α, IL-6, and IL-1β in the serum.
Reduced oxidative stress in the brain tissue, as shown by decreased ROS and MDA levels and increased iNOS activity and protein expression.
Ameliorated neuronal cell apoptosis, as indicated by the reduced expression of Bax and caspase-3 and increased expression of Bcl-2, and decreased the number of TUNEL-positive cells in the hippocampus.
Regulated the JNK/ERK/Akt pathway, reducing the expression of p-JNK/JNK and p-ERK/ERK and increasing the expression of p-Akt/Akt.
Improved cognitive function, as shown by increased time spent in the target quadrant and number of crossings and decreased escape latency, and reduced the neurological score.

Chemical Information

No. CAS 33708-72-4
Appearance Solid
Peso molecular 344.32
Fòrmula C₁₈H₁₆O₇
Color White to yellow
SMILES

O=C1C(OC)=C(C2=CC(OC)=C(O)C=C2)OC3=CC(OC)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Nat Biomed Eng

DeepDrugDiscovery identifies blood-brain barrier permeable autophagy enhancers for Alzheimer's disease. [Abstract]

2026 Apr 24. PMID: 42032039

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (290.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9043 mL

14.5214 mL

29.0428 mL

5 mM

0.5809 mL

2.9043 mL

5.8085 mL

10 mM

0.2904 mL

1.4521 mL

2.9043 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kim EK, et al. Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Int J Mol Sci. 2019;20(17):4082. Published 2019 Aug 21. [Content Brief]

[2]. Ali HA,et al. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res. 2008;22(12):1684-1687. [Content Brief]

[3]. Zahara S S, et al. Pachypodol attenuates arsenic triggered cardiac damage via rectifying oxidative stress, inflammation, apoptosis and histopathological alterations. Journal of King Saud University-Science, 2024, 36(7): 103260.

[4]. Zhang J, et al. Pachypodol protects newborn rats from anaesthesia-induced apoptosis in the developing brain by regulating the JNK/ERK pathway. Int J Dev Neurosci. 2021 Nov;81(7):633-642. [Content Brief]

[5]. Ijaz M U, et al. Pachypodol, a Plant Flavonoid, Mitigates Cisplatin-Induced Hepatotoxicity Through Anti-Oxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms. J. Food Nutr. Res., 2023, 11: 513-518.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9043 mL	14.5214 mL	29.0428 mL	72.6069 mL
	5 mM	0.5809 mL	2.9043 mL	5.8086 mL	14.5214 mL
	10 mM	0.2904 mL	1.4521 mL	2.9043 mL	7.2607 mL
	15 mM	0.1936 mL	0.9681 mL	1.9362 mL	4.8405 mL
	20 mM	0.1452 mL	0.7261 mL	1.4521 mL	3.6303 mL
	25 mM	0.1162 mL	0.5809 mL	1.1617 mL	2.9043 mL
	30 mM	0.0968 mL	0.4840 mL	0.9681 mL	2.4202 mL
	40 mM	0.0726 mL	0.3630 mL	0.7261 mL	1.8152 mL
	50 mM	0.0581 mL	0.2904 mL	0.5809 mL	1.4521 mL
	60 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2101 mL
	80 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9076 mL
	100 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7261 mL

Keywords

Pachypodol

1 Cited Publications

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Pachypodol

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Publications Citing Use of MedChemExpress (MCE) Pachypodol

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Pachypodol Related Classifications

HY-N3121 Related Classifications