Panobinostat (Standard)
Based on 1 Customer Validation
Panobinostat (Standard) (LBH589 (Standard)) is the analytical standard of Panobinostat (HY-10224). This product is intended for research and analytical applications. Panobinostat is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.09%
- No. CAS: 404950-80-7
- Fòrmula: C21H23N3O2
- Peso molecular:349.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 404950-80-7
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Appearance Solid
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Peso molecular 349.43
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Fòrmula C21H23N3O2
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Color Off-white to light yellow
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SMILES
ONC(/C=C/C(C=C1)=CC=C1CNCCC2=C(C)NC3=CC=CC=C23)=O
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Synonyms
LBH589 (Standard); NVP-LBH589 (Standard)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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SDS (745 KB)
- English - EN (745 KB)
- Français - FR (745 KB)
- Deutsch - DE (745 KB)
- Norwegian - NO (745 KB)
- Español - ES (745 KB)
- Swedish - SV (745 KB)
- Italian - IT (745 KB)
- Korean - KR (745 KB)
- Portuguese - PT (745 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [Content Brief]
[2]. Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [Content Brief]
[4]. Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Panobinostat (Standard) Related Classifications
HY-10224R Related Classifications
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