Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
Norepinephrine transporter inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "Norepinephrine transporter inhibitor" in MCE Product Catalog:
Referencia número: HY-N2426R
No. CAS: 119738-57-7
Referencia número: HY-B0602R
No. CAS: 93413-62-8
Synonyms: O-Desmethylvenlafaxine (Standard)
Áreas de investigación:
Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
Referencia número: HY-18332
No. CAS: 410074-73-6
Synonyms: DOV-21947; EB-1010
Áreas de investigación:
Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.
Referencia número: HY-B0193AR
No. CAS: 19237-84-4
Áreas de investigación:
Prazosin (hydrochloride) (Standard) is the analytical standard of Prazosin (hydrochloride). This product is intended for research and analytical applications. Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
Referencia número: HY-107370S
No. CAS: 919104-07-7
Synonyms: Tomoxetine-d7; (R)-Tomoxetine-d7
Referencia número: HY-107370S1
No. CAS: 1129478-03-0
Synonyms: Tomoxetine-d5; (R)-Tomoxetine-d5
Referencia número: HY-W380450R
No. CAS: 46817-91-8
Synonyms: Viloxazin (Standard); Emovit (Standard)
Target:
Áreas de investigación:
Viloxazine is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC50= 0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (Ki=4.2 μM) and agonizes 5-HT2C receptors (EC50= 32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD) .
Referencia número: HY-148862
No. CAS: 2314361-39-0
Target:
Áreas de investigación:
Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain .
Referencia número: HY-U00069
No. CAS: 155273-01-1
Target:
Áreas de investigación:
Thionisoxetine is a norepinephrine transporter inhibitor with a Ki value of 0.2 nM in rats, and exhibits anti-hyperalgesic and analgesic activities. Thionisoxetine reverses thermal hyperalgesia and mechanical allodynia in rats. Thionisoxetine can be used in studies related to persistent inflammatory pain .
Referencia número: HY-107128R
No. CAS: 1227056-87-2
Synonyms: TD-9855 hydrochloride (Standard)
Áreas de investigación:
Ampreloxetine hydrochloride (Standard) (TD-9855 hydrochloride (Standard)) is the analytical standard of Ampreloxetine (hydrochloride) (HY-107128). This product is intended for research and analytical applications. Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .
Referencia número: HY-106604
No. CAS: 70384-91-7
Synonyms: LM 1404
Target:
Áreas de investigación:
Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake .
Referencia número: HY-N9628
No. CAS: 946839-55-0
Target:
Referencia número: HY-W279140
No. CAS: 16154-78-2
Synonyms: Pyrazidole hydrochloride; Pirazidole hydrochloride
Áreas de investigación:
Pirlindole (Pyrazidole; Pirazidole) hydrochloride is an orally active, selective, reversible, blood-brain barrier-permeable MAO-A inhibitor with weak inhibitory effects on norepinephrine transporters and serotonin transporters. Pirlindole hydrochloride secondarily inhibits the reuptake of norepinephrine and serotonin to elevate central neurotransmitter levels, thereby producing antidepressant effects, and also exhibits multiple activities including anticonvulsant, analgesic, local anesthetic, blood pressure-regulating, and platelet aggregation-inhibiting properties. Pirlindole hydrochloride is widely applicable to research on major depressive disorder and related depressive conditions .
Referencia número: HY-186094
No. CAS: 105018-14-2
Target:
Áreas de investigación:
(S,S)-Demethyl-reboxetine is a key phenolic precursor for the preparation of the PET tracer (S,S)-[ 11C]-MeNER. (S,S)-Demethyl-reboxetine is also the demethylated derivative of Reboxetine (HY-14560). Efficient synthesis of the norepinephrine transporter (NET)-targeted tracer is achieved through 11C methylation of (S,S)-Demethyl-reboxetine. (S,S)-Demethyl-reboxetine serves as a core raw material for the synthesis of radiopharmaceuticals related to NET imaging .
Referencia número: HY-182247
No. CAS: 1632000-05-5
Áreas de investigación:
D-473 is an orally active, blood-brain barrier penetrant and serotonin-preferring reuptake inhibitor. D-473 inhibits serotonin, dopamine and norepinephrine transporters, and significantly elevates the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits definite antidepressant-like activity without inducing motor activation. D-473 is widely used in studies related to major depressive disorder .
Referencia número: HY-17385S1
Synonyms: Tomoxetine-d7 hydrochloride; (R)-Tomoxetine-d7 hydrochloride
Referencia número: HY-179568
No. CAS: 926493-93-8
Target:
Áreas de investigación:
F3288-0031 is a brain-penetrant norepinephrine transporter (NET) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET, stabilizing the inward-open state and has a preferential NET/SERT inhibition with pIC50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions .
Referencia número: HY-W680886
No. CAS: 152623-93-3
Áreas de investigación:
6-APDB is a class of monoamine neurotransmitter releaser and Monoamine Transporter modulator that exerts selective effects on human monoamine transporters and acts as a partial agonist at 5-HT2 family receptors. For NET, 6-APDB has an IC50 of 0.56 μM and a Ki of 18 μM; for SERT, it has an IC50 of 2.3 μM and a Ki of 23 μM; for DAT, it has an IC50 of 33 μM and a Ki of >30 μM, and affinity for rat and mouse TAAR1, with Ki values of 1.0 μM and 0.21 μM, respectively. 6-APDB inhibits norepinephrine and 5-HT reuptake, mediates the release of three types of monoamine neurotransmitters, shows a dose-dependent biphasic locomotor effect in mice, and fully substitutes the discriminative stimulus effect of MDMA. 6-APDB shows no significant cytotoxicity at high concentrations, and possesses empathogenic psychoactivity, potential hallucinogenic effects, and behavioral effects associated with intermittent abuse .
Referencia número: HY-183482
No. CAS: 77862-94-3
Target:
Áreas de investigación:
GBR 13098 is a dopamine transporter inhibitor with a rat IC50 of 43 nM, and exhibits dopaminergic activity in vivo .GBR 13098 selectively blocks dopamine uptake, increasing synaptic dopamine availability, with weaker activity against norepinephrine uptake .GBR 13098 induces ipsilateral circling in lesioned rats and increases locomotor activity in naive mice and habituated rats, with effects attenuated by dopamine receptor antagonism .GBR 13098 reduces DOPA formation in dopamine-rich brain regions and enhances inhibitory responses of substantia nigra zona compacta dopamine neurons to dopamine .GBR 13098 serves as a pharmacological agent for studying dopaminergic systems .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
