16154-78-2
Chemical Structure
Pirlindole hydrochloride
Synonym(s): Pyrazidole hydrochloride; Pirazidole hydrochloride
- CAS No.: 16154-78-2
- Formula:C15H19ClN2
- Molecular Weight:262.78
IUPAC Name: 8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride
InChIKey: LIFOOCLGAAEVIF-UHFFFAOYSA-N
SMILES: CC1=CC(C2=C3N4CCNC3CCC2)=C4C=C1.Cl
Biological Activity: Pirlindole (Pyrazidole; Pirazidole) hydrochloride is an orally active, selective, reversible, blood-brain barrier-permeable MAO-A inhibitor with weak inhibitory effects on norepinephrine transporters and serotonin transporters. Pirlindole hydrochloride secondarily inhibits the reuptake of norepinephrine and serotonin to elevate central neurotransmitter levels, thereby producing antidepressant effects, and also exhibits multiple activities including anticonvulsant, analgesic, local anesthetic, blood pressure-regulating, and platelet aggregation-inhibiting properties. Pirlindole hydrochloride is widely applicable to research on major depressive disorder and related depressive conditions[1][2].
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Pirlindole hydrochloride | Pirlindole (Pyrazidole; Pirazidole) hydrochloride is an orally active, selective, reversible, blood-brain barrier-permeable MAO-A inhibitor with weak inhibitory effects on norepinephrine transporters and serotonin transporters. Pirlindole hydrochloride secondarily inhibits the reuptake of norepinephrine and serotonin to elevate central neurotransmitter levels, thereby producing antidepressant effects, and also exhibits multiple activities including anticonvulsant, analgesic, local anesthetic, blood pressure-regulating, and platelet aggregation-inhibiting properties. Pirlindole hydrochloride is widely applicable to research on major depressive disorder and related depressive conditions. | |||||||||||||||||||||
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- [1]. Macedo A, et al. Pirlindole in the treatment of depression: a meta-analysis. Clinical drug investigation. 2011;31(1):61-71. [Content Brief]
- [2]. Bruhwyler J, et al. Pirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties. Pharmacological research. 1997 Jul;36(1):23-33. [Content Brief]
Keywords
