2314361-39-0
Chemical Structure
Cavα2δ1&NET-IN-1
- CAS No.: 2314361-39-0
- Formula:C23H26N4O2S
- Molecular Weight:422.54
IUPAC Name: (S)-1-methyl-4-(3-(3-(methylamino)-1-(thiophen-2-yl)propoxy)phenyl)-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one
InChIKey: UYQPTSPEQOJDJK-FQEVSTJZSA-N
SMILES: O=C1N(CCN(C2=NC=CC=C21)C)C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3
Biological Activity: Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain[1].
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Cavα2δ1&NET-IN-1 | Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain. | |||||||||||||||||||||
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Keywords
