77862-94-3
Chemical Structure
GBR 13098
- CAS No.: 77862-94-3
- Formula:C30H39F3N2O7S2
- Molecular Weight:660.77
InChIKey: HDZUAWFACXESQE-UHFFFAOYSA-N
SMILES: CS(=O)(O)=O.CS(=O)(O)=O.FC1=CC=C(CCCN2CCN(CCOC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2)C=C1
Biological Activity: GBR 13098 is a dopamine transporter inhibitor with a rat IC50 of 43 nM, and exhibits dopaminergic activity in vivo[1].GBR 13098 selectively blocks dopamine uptake, increasing synaptic dopamine availability, with weaker activity against norepinephrine uptake[2].GBR 13098 induces ipsilateral circling in lesioned rats and increases locomotor activity in naive mice and habituated rats, with effects attenuated by dopamine receptor antagonism[1][2].GBR 13098 reduces DOPA formation in dopamine-rich brain regions and enhances inhibitory responses of substantia nigra zona compacta dopamine neurons to dopamine[2].GBR 13098 serves as a tool for studying dopaminergic systems[1].
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GBR 13098 | GBR 13098 is a dopamine transporter inhibitor with a rat IC50 of 43 nM, and exhibits dopaminergic activity in vivo.GBR 13098 selectively blocks dopamine uptake, increasing synaptic dopamine availability, with weaker activity against norepinephrine uptake.GBR 13098 induces ipsilateral circling in lesioned rats and increases locomotor activity in naive mice and habituated rats, with effects attenuated by dopamine receptor antagonism.GBR 13098 reduces DOPA formation in dopamine-rich brain regions and enhances inhibitory responses of substantia nigra zona compacta dopamine neurons to dopamine.GBR 13098 serves as a tool for studying dopaminergic systems. | |||||||||||||||||||||
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- [1]. Heikkila RE, et al. Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. European journal of pharmacology. 1984 Aug 17;103(3-4):241-8. [Content Brief]
- [2]. Pileblad E, et al. GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies. Naunyn-Schmiedeberg's archives of pharmacology. 1986 Dec;334(4):383-7. [Content Brief]
Keywords
