Sergliflozin-A
Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
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- No. CAS: 360775-96-8
- Fòrmula: C20H24O7
- Peso molecular:376.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
|
SGLT1 |
SGLT2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
9.2 nM
Compound: 4a
|
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | EC50 |
>8000 nM
Compound: 4a
|
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | IC50 |
6.25 nM
Compound: 6
|
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
|
[PMID: 20181486] |
| CHO | IC50 |
2300 nM
Compound: 3-active
|
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
|
[PMID: 21873071] |
| CHO | IC50 |
4.8 nM
Compound: 3-active
|
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
|
[PMID: 21873071] |
| CHO-K1 | IC50 |
2300 nM
Compound: 2-A
|
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
|
[PMID: 22652255] |
| CHO-K1 | IC50 |
4.8 nM
Compound: 2-A
|
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
|
[PMID: 22652255] |
Chemical Information
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No. CAS 360775-96-8
-
Peso molecular 376.40
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Fòrmula C20H24O7
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SMILES
COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)