SSTR3 agonist-1 TFA
SSTR3 agonist-1 TFA is a potent, orally active, and selective SSTR3 agnoist (EC50 =0.14 nM). SSTR3 agonist-1 TFA binds to SSTR3 receptor to inhibit cAMP activity. SSTR3 agonist-1 TFA decreases kidney weight and kidney cystic index (KCI) in a mouse model of autosomal dominant polycystic kidney disease (ADPKD). SSTR3 agonist-1 TFA can be used for ADPKD research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C33H38F7N5O6
- Peso molecular:733.67
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Almacenamiento:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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SSTR3 0.14 nM (EC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pax8 Tet-O-Cre/Pkd1 flox mice treated with Doxycycline (HY-N0565) hyclate (50 mg/kg) to induce ADPKD[1]
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Dosage:30 and 60 mg/kg
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Administration:p.o., daily for 9 days from (PND) 12 to 20
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Result:Decreased KCI with a 10.7% suppression compared to the vehicle at 30 mg/kg.
Decreased KCI with a 25.2% suppression compared to the vehicle at 60 mg/kg.
Dose dependently decreased the left kidney weight/body weight (LKW/BW) ratio.
Chemical Information
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Appearance Solid
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Peso molecular 733.67
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Fòrmula C33H38F7N5O6
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Color Yellow to brown
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SMILES
O=C(C1=C(N=C2C=C(C(OC)=CC2=C1N3CC[C@H](C)NCC3)C(F)(F)F)N4CCOCC4)N[C@@H](C)C5=CC(OC)=C(F)C=C5.O=C(O)C(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SSTR3 agonist-1 TFA Related Classifications
HY-177493A Related Classifications
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