Thalidomide-5-COOH
Based on 1 Customer Validation
Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs.
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- Pureza: 99.94%
- No. CAS: 1216805-11-6
- Fòrmula: C14H10N2O6
- Peso molecular:302.24
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1216805-11-6
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Appearance Solid
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Peso molecular 302.24
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Fòrmula C14H10N2O6
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Color Gray to gray purple
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SMILES
O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 125 mg/mL (413.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3086 mL | 16.5431 mL | 33.0863 mL | 82.7157 mL |
| 5 mM | 0.6617 mL | 3.3086 mL | 6.6173 mL | 16.5431 mL | |
| 10 mM | 0.3309 mL | 1.6543 mL | 3.3086 mL | 8.2716 mL | |
| 15 mM | 0.2206 mL | 1.1029 mL | 2.2058 mL | 5.5144 mL | |
| 20 mM | 0.1654 mL | 0.8272 mL | 1.6543 mL | 4.1358 mL | |
| 25 mM | 0.1323 mL | 0.6617 mL | 1.3235 mL | 3.3086 mL | |
| 30 mM | 0.1103 mL | 0.5514 mL | 1.1029 mL | 2.7572 mL | |
| 40 mM | 0.0827 mL | 0.4136 mL | 0.8272 mL | 2.0679 mL | |
| 50 mM | 0.0662 mL | 0.3309 mL | 0.6617 mL | 1.6543 mL | |
| 60 mM | 0.0551 mL | 0.2757 mL | 0.5514 mL | 1.3786 mL | |
| 80 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0339 mL | |
| 100 mM | 0.0331 mL | 0.1654 mL | 0.3309 mL | 0.8272 mL |
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