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Referencia número: HY-12328

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Trk-IN-2

Trk-IN-2 is an orally active pan-Trk kinase inhibitor with an TrkA IC₅₀ of 9 nM. Trk-IN-2 exhibits pharmacodynamic effects in rat models of inflammatory pain and neuropathic pain.Trk-IN-2 can be used for the research of inflammatory pain, neuropathic pain.

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No. CAS: 1614229-04-7
Fòrmula: C₂₄H₂₄N₁₀O
Peso molecular:468.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Trk-IN-2 Chemical Structure

No. CAS: 1614229-04-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	7 nM Compound: 11	Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay	[PMID: 24914455]

In Vitro

Trk-IN-2 (compound 11) inhibits TrkA with an IC₅₀ of 7 nM in cell-based assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1614229-04-7
Peso molecular 468.53
Fòrmula C₂₄H₂₄N₁₀O
SMILES

O=C(NC1=CC(=NN1C=2C=NC=CC2)C(C)(C)C)CN3N=NC(=C3)C=4C=NC(=CC4)N5C=NC=C5
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Norman BH, et al. Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017;60(1):66-88. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Trk-IN-2

Ver todos los productos específicos de isoformas Trk Receptor

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Trk-IN-2 Related Classifications

HY-12328 Related Classifications