Smpdl3b - sphingomyelin phosphodiesterase, acid-like 3B Gene

Mus musculus

Also known as Asml3b; 1110054A24Rik

Gene ID: 100340 | Gene type: protein coding

About Smpdl3b

Summary

Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in membrane lipid catabolic process; negative regulation of inflammatory response; and negative regulation of Toll-like Receptor signaling pathway. Located in plasma membrane. Orthologous to human SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). [provided by Alliance of Genome Resources, Apr 2022]

Smpdl3b Products(1)

mRNA	Protein	Name
NM_133888.2	NP_598649.1	acid sphingomyelinase-like phosphodiesterase 3b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoric diester hydrolase activity	IDA IDA: Inferred from direct assay	27687724	MGI
enables phosphoric diester hydrolase activity	IMP IMP: Inferred from mutant phenotype	26095358	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26095358	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	27687724	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in membrane lipid catabolic process	IMP IMP: Inferred from mutant phenotype	26095358	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	26095358	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26095358	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	26095358	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acid sphingomyelinase-like phosphodiesterase 3b

ASM-like phosphodiesterase 3b

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13452	SMPDL3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smpdl3b	NCBI	NCBI:27293

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