APELA - apelin receptor early endogenous ligand Gene

Also Known as ELA; tdl; Ende

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 100506013

About APELA

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:164,877,178-164,899,007 (from NCBI)

This gene has 5 transcripts (splice variants) and 16 orthologues. Biased expression in prostate (RPKM 1.8), kidney (RPKM 0.5) and 2 other tissues.

Summary

This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/Akt pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]

APELA Products (1)

mRNA Protein Name
NM_001297550.2 NP_001284479.1 apelin receptor early endogenous ligand precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables apelin receptor binding IDA
IDA: Inferred from direct assay
28137936 GOA
enables hormone activity IMP
IMP: Inferred from mutant phenotype
25639753 GOA
Biological Process GO Annotation Evidence References Source
involved in apelin receptor signaling pathway IDA
IDA: Inferred from direct assay
25639753 GOA
involved in apelin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28137936 GOA
involved in positive regulation of G protein-coupled receptor internalization IMP
IMP: Inferred from mutant phenotype
25639753 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
25639753 GOA
involved in positive regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
28663440 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
24316148 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apelin receptor early endogenous ligand

  • protein Elabela

Related Diseases

Diseases Alias
Thyroid Cancer, Nonmedullary, 1

  • Papillary Thyroid Carcinoma

  • Familial Nonmedullary Thyroid Cancer, Papillary

  • Nonmedullary Thyroid Carcinoma, Papillary

  • Papillary Thyroid Cancer

  • NMTC1

  • Papillary Carcinoma Of Thyroid

  • Pact

  • Thyroid Carcinoma, Papillary

  • Non-Medullary Thyroid Carcinoma

  • Thyroid Cancer, Non-Medullary, 1

  • Familial Non-Medullary Thyroid Cancer

  • Fnmtc

  • Nmtc

  • Nonmedullary Thyroid Carcinoma

  • Ptc

  • Tpc

  • Thyroid Papillary Carcinoma

  • Cancer, Thyroid, Nonmedullary

  • Cancer, Thyroid, Nonmedullary, Type 1

  • Thyroid Carcinoma, Nonmedullary 1

  • Familial Nonmedullary Thyroid Gland Carcinoma

  • Papillary Carcinoma, Diffuse Sclerosing, Thyroid Gland
46,Xy Sex Reversal 8

  • SRXY8

  • Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

  • Tdd

  • 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

  • 46xy Sex Reversal 8

  • 46xy Sex Reversal 8, Modifier Of

  • Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
N Syndrome

  • NSX

  • Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00814 APELA Human Pre-designed siRNA Set A Pre-designed Set / Unkown