Psme4 - proteasome (prosome, macropain) activator subunit 4 Gene

Also Known as TEMO; mKIAA0077

Species: Mus musculus

Gene Type: protein coding
Gene ID: 103554

Summary

Enables lysine-acetylated histone binding activity and peptidase activator activity. Involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in cytosol and nucleus. Part of spermatoproteasome complex. Is expressed in craniocervical region bone; ganglia; sensory organ; and submandibular gland primordium. Used to study visceral heterotaxy. Orthologous to human PSME4 (Proteasome activator subunit 4). [provided by Alliance of Genome Resources, Apr 2022]

Psme4 Products (1)

mRNA Protein Name
NM_134013.3 NP_598774.2 proteasome activator complex subunit 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
23706739 MGI
enables peptidase activator activity IDA
IDA: Inferred from direct assay
23706739 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23706739 MGI
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
23706739 MGI
involved in proteasomal ubiquitin-independent protein catabolic process IDA
IDA: Inferred from direct assay
23706739 MGI
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
23706739 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23706739 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23706739 MGI
part of spermatoproteasome complex IDA
IDA: Inferred from direct assay
23706739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteasome activator complex subunit 4

  • proteasome activator PA200

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11334 PSME4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psme4 NCBI NCBI:23198