Psme4 - proteasome (prosome, macropain) activator subunit 4 Gene

Mus musculus

Also known as TEMO; mKIAA0077

Gene ID: 103554 | Gene type: protein coding

About Psme4

Summary

Enables lysine-acetylated histone binding activity and peptidase activator activity. Involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in cytosol and nucleus. Part of spermatoproteasome complex. Is expressed in craniocervical region bone; ganglia; sensory organ; and submandibular gland primordium. Used to study visceral heterotaxy. Orthologous to human PSME4 (Proteasome activator subunit 4). [provided by Alliance of Genome Resources, Apr 2022]

Psme4 Products(1)

mRNA	Protein	Name
NM_134013.3	NP_598774.2	proteasome activator complex subunit 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	23706739	MGI
enables peptidase activator activity	IDA IDA: Inferred from direct assay	23706739	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	23706739	MGI
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	23706739	MGI
involved in proteasomal ubiquitin-independent protein catabolic process	IDA IDA: Inferred from direct assay	23706739	MGI
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	23706739	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	23706739	MGI
located in nucleus	IDA IDA: Inferred from direct assay	23706739	MGI
part of spermatoproteasome complex	IDA IDA: Inferred from direct assay	23706739	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proteasome activator complex subunit 4

proteasome activator PA200

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11334	PSME4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Psme4	NCBI	NCBI:23198

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