Airn - antisense Igf2r RNA Gene

Also Known as Air; IGF2RAS; D17Ertd663e; 2810051F02Rik; 2810434M15Rik; B930018I07Rik

Species: Mus musculus

Gene Type: ncRNA
Gene ID: 104103

Summary

This gene is a paternally expressed imprinted gene. Alternatively spliced transcript variants have been produced from this gene and they are all long non-coding RNAs. These variants share the same 5' exon, and their 3' exons are divergent. The 5' exon overlaps the intron 2 of the Igf2r gene on the opposite strand. The Igf2r intron 2 contains a CpG island, which is a promoter and drives the expression of this gene. This gene is responsible for silencing Igf2r, and the flanking Slc22a2 and Slc22a3 genes in the imprinted gene cluster. It regulates transcription of these genes through epigenetic modifications. [provided by RefSeq, Jan 2013]

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
11845212 MGI
acts upstream of or within protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
18988810 MGI
acts upstream of regulatory ncRNA-mediated heterochromatin formation IMP
IMP: Inferred from mutant phenotype
18988810 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear chromosome IDA
IDA: Inferred from direct assay
18988810 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Orthologs Information

Species Symbol Source ID
Homo sapiens Airn NCBI NCBI:100271873