Pkdcc - protein kinase domain containing, cytoplasmic Gene

Also Known as Vlk; MAd1; Adtk1; ESTM17; Sgk493

Species: Mus musculus

Gene Type: protein coding

Gene ID: 106522

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including negative regulation of Golgi to plasma membrane protein transport; positive regulation of bone mineralization; and positive regulation of chondrocyte differentiation. Acts upstream of or within bone mineralization; limb morphogenesis; and skeletal system development. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including alimentary system; arm; embryo ectoderm; embryo mesenchyme; and mesothelium. Orthologous to human PKDCC (protein kinase domain containing, cytoplasmic). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	25171405	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	19465597	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	21553379	MGI
involved in embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	19097194	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	21553379	MGI
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	19465597	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	21553379	MGI
involved in negative regulation of Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	19465597	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	25171405	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	19097194	MGI
involved in positive regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19097194	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	19097194	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	21553379	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19465597	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	25171405	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
extracellular tyrosine-protein kinase PKDCC	protein kinase domain-containing protein, cytoplasmic protein kinase-like protein SgK493 sugen kinase 493 vertebrate lonesome kinase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10595	PKDCC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkdcc	NCBI	NCBI:91461