Slc12a6 - solute carrier family 12, member 6 Gene

Also Known as KCC3; gaxp; 9530023I19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107723

Summary

Enables protein kinase binding activity. Predicted to be involved in several processes, including cellular hypotonic salinity response; inorganic ion homeostasis; and inorganic ion transmembrane transport. Located in axon and basolateral plasma membrane. Is expressed in olfactory epithelium; spiral ligament; telencephalon ventricular layer; and vomeronasal organ. Used to study agenesis of the corpus callosum with peripheral neuropathy and motor peripheral neuropathy. Human ortholog(s) of this gene implicated in agenesis of the corpus callosum with peripheral neuropathy. Orthologous to human SLC12A6 (solute carrier family 12 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a6 Products (3)

mRNA Protein Name
NM_001362700.1 NP_001349629.1 solute carrier family 12 member 6 isoform 3
NM_133648.2 NP_598409.2 solute carrier family 12 member 6 isoform 1
NM_133649.2 NP_598410.2 solute carrier family 12 member 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium:chloride symporter activity IDA
IDA: Inferred from direct assay
10347194 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12386165 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
27782176 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
24089410 MGI
involved in chloride ion homeostasis IDA
IDA: Inferred from direct assay
10347194 MGI
involved in potassium ion homeostasis IDA
IDA: Inferred from direct assay
10347194 MGI
Cellular Component GO Annotation Evidence References Source
NOT located in apical plasma membrane IDA
IDA: Inferred from direct assay
11246162 MGI
located in axon IDA
IDA: Inferred from direct assay
11246162 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11246162 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10347194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 6

  • K-Cl cotransporter 3

  • electroneutral potassium-chloride cotransporter 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13001 SLC12A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a6 NCBI NCBI:9990