Chn1 - chimerin 1 Gene

Also Known as ARHGAP2; 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108699

Summary

Enables Ephrin Receptor binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; motor neuron axon guidance; and regulation of GTPase activity. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Used to study Duane retraction syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to human CHN1 (chimerin 1). [provided by Alliance of Genome Resources, Apr 2022]

Chn1 Products (5)

mRNA Protein Name
NM_001113246.2 NP_001106717.2 N-chimaerin isoform 3
NM_001166603.1 NP_001160075.1 N-chimaerin isoform 4
NM_001166604.1 NP_001160076.1 N-chimaerin isoform 5
NM_029716.3 NP_083992.1 N-chimaerin isoform 2
NM_175752.3 NP_786928.2 N-chimaerin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
17719550 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17719550 MGI
Biological Process GO Annotation Evidence References Source
involved in ephrin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17785183 MGI
involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
17785183 MGI
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
17719550 MGI
involved in regulation of axonogenesis IDA
IDA: Inferred from direct assay
17719550 MGI
involved in regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
17785183 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-chimaerin

  • A-chimaerin

  • N-chimerin

  • NC

  • alpha-chimerin

  • alpha1 chimaerin

  • alpha2 chimaerin

  • alpha3-chimerin

  • chimaerin

  • chimerin (chimaerin) 1

  • rho GTPase-activating protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02649 CHN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20259 Chn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26767 Chn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chn1 NCBI NCBI:1123