Lmx1a - LIM homeobox transcription factor 1 alpha Gene

Mus musculus

Also known as dr; sst; Lmx1.1; dreher

Gene ID: 110648 | Gene type: protein coding

About Lmx1a

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including memory; midbrain dopaminergic neuron differentiation; and olfactory behavior. Acts upstream of or within several processes, including negative regulation of neuron differentiation; nervous system development; and regulation of cell growth. Predicted to be active in nucleus. Is expressed in several structures, including brain; ear; embryo ectoderm; genitourinary system; and notochord. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lmx1a Products(1)

mRNA	Protein	Name
NM_033652.5	NP_387501.1	LIM homeobox transcription factor 1-alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19951692	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19951692	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15183721	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	15148302	MGI
acts upstream of central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	15148302	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	17670789	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	1638738	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	1638738	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	21752929	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	1638738	MGI
involved in locomotory behavior	IGI IGI: Inferred from genetic interaction	25915474	MGI
involved in memory	IGI IGI: Inferred from genetic interaction	25915474	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	21752929	MGI
involved in midbrain dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	19951692	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15148302	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15183721	MGI
involved in olfactory behavior	IGI IGI: Inferred from genetic interaction	25915474	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19951692	MGI
acts upstream of or within regulation of cell growth	IMP IMP: Inferred from mutant phenotype	17670789	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17670789	MGI
involved in synapse organization	IGI IGI: Inferred from genetic interaction	25915474	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LIM homeobox transcription factor 1-alpha

LIM/homeobox protein 1.1	LIM/homeobox protein LMX1A
LMX-1.1	shaker short-tail

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07727	LMX1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174589	Human LMX1A mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lmx1a	NCBI	NCBI:4009

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