Lmx1a - LIM homeobox transcription factor 1 alpha Gene

Also Known as dr; sst; Lmx1.1; dreher

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110648

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including memory; midbrain dopaminergic neuron differentiation; and olfactory behavior. Acts upstream of or within several processes, including negative regulation of neuron differentiation; nervous system development; and regulation of cell growth. Predicted to be active in nucleus. Is expressed in several structures, including brain; ear; embryo ectoderm; genitourinary system; and notochord. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 7. Orthologous to human LMX1A (LIM homeobox transcription factor 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Lmx1a Products (1)

mRNA Protein Name
NM_033652.5 NP_387501.1 LIM homeobox transcription factor 1-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19951692 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19951692 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15183721 MGI
acts upstream of or within central nervous system development IMP
IMP: Inferred from mutant phenotype
15148302 MGI
acts upstream of central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
15148302 MGI
acts upstream of or within central nervous system neuron differentiation IMP
IMP: Inferred from mutant phenotype
17670789 MGI
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
1638738 MGI
acts upstream of or within dentate gyrus development IMP
IMP: Inferred from mutant phenotype
1638738 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
21752929 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
1638738 MGI
involved in locomotory behavior IGI
IGI: Inferred from genetic interaction
25915474 MGI
involved in memory IGI
IGI: Inferred from genetic interaction
25915474 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
21752929 MGI
involved in midbrain dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
19951692 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15148302 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
15183721 MGI
involved in olfactory behavior IGI
IGI: Inferred from genetic interaction
25915474 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19951692 MGI
acts upstream of or within regulation of cell growth IMP
IMP: Inferred from mutant phenotype
17670789 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17670789 MGI
involved in synapse organization IGI
IGI: Inferred from genetic interaction
25915474 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM homeobox transcription factor 1-alpha

  • LIM/homeobox protein 1.1

  • LIM/homeobox protein LMX1A

  • LMX-1.1

  • shaker short-tail

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07727 LMX1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174589 Human LMX1A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmx1a NCBI NCBI:4009