Erc1 - ELKS/RAB6-interacting/CAST family member 1 Gene

Mus musculus

Also known as ELKS; CAST2; Elks1; Rab6ip2; RAB6IP2A; RAB6IP2B; mKIAA1081; 4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik

Gene ID: 111173 | Gene type: protein coding

About Erc1

Summary

Enables small GTPase binding activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. A structural constituent of presynaptic active zone. Involved in synaptic vesicle priming. Acts upstream of or within retrograde transport, endosome to Golgi. Located in GABA-ergic synapse; cytoplasm; and glutamatergic synapse. Is expressed in several structures, including genitourinary system; gut gland; oral epithelium; retina; and telencephalon. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Erc1 Products(2)

mRNA	Protein	Name
NM_053204.2	NP_444434.2	ELKS/Rab6-interacting/CAST family member 1 isoform 1
NM_178085.3	NP_835186.1	ELKS/Rab6-interacting/CAST family member 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11929610	MGI
enables small GTPase binding	IDA IDA: Inferred from direct assay	11929610	MGI
enables structural constituent of presynaptic active zone	IDA IDA: Inferred from direct assay	27537483	MGI
enables structural constituent of presynaptic active zone	IEP IEP: Inferred from expression pattern	27537483	MGI
enables structural constituent of presynaptic active zone	IMP IMP: Inferred from mutant phenotype	27537483	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	25209271	MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	25209271	MGI
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	25209271	MGI
involved in regulation of presynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	25209271	MGI
acts upstream of or within retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	11929610	MGI
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	27253063	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	27253063	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25209271	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25209271	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11929610	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27253063	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27253063	MGI
located in podosome	IDA IDA: Inferred from direct assay	23525008	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	32521280	MGI
located in synapse	IDA IDA: Inferred from direct assay	23791195	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ELKS/Rab6-interacting/CAST family member 1

CAZ-associated structural protein 2	RAB6-interacting protein 2
Rab6 interacting protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04476	ERC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erc1	NCBI	NCBI:23085

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