2. Gene
  3. RFFL - ring finger and FYVE like domain containing E3 ubiquitin protein ligase Gene

RFFL - ring finger and FYVE like domain containing E3 ubiquitin protein ligase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN

Gene ID: 117584 | Gene type: protein coding

About RFFL

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,005,990-35,089,226 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 18.0), esophagus (RPKM 12.3) and 25 other tissues.

Summary

Enables Enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RFFL Products(1)

mRNA Protein Name
NM_001017368.2 NP_001017368.1 E3 ubiquitin-protein ligase rififylin

RFFL Protein Structure

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (313 - 354)

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  • 363 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase rififylin

FYVE-RING finger protein SAKURA

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11871 RFFL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RFFL RGD RGD:727916
Bos taurus RFFL VGNC VGNC:57149
Felis catus RFFL VGNC VGNC:97603
Mus musculus RFFL MGD MGI:1914588