RFFL - ring finger and FYVE like domain containing E3 ubiquitin protein ligase Gene

Also Known as CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117584

About RFFL

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,005,990-35,089,226 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 18.0), esophagus (RPKM 12.3) and 25 other tissues.

Summary

Enables enzyme binding activity; p53 binding activity; and ubiquitin protein Ligase activity. Involved in cellular protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; and negative regulation of signal transduction. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RFFL Products (1)

mRNA	Protein	Name
NM_001017368.2	NP_001017368.1	E3 ubiquitin-protein ligase rififylin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	17121812	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	15069192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22609986	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18450452	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	17121812	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18382127	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	15069192	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15069192	GOA
involved in negative regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17121812	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18450452	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18382127	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	18450452	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15069192	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18450452	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in Golgi membrane	IDA IDA: Inferred from direct assay	18450452	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15069192	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	18450452	GOA
NOT located in lysosome	IDA IDA: Inferred from direct assay	18450452	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15069192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RFFL Protein Structure

zf-C3HC4_3

0
100
200
300
363 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase rififylin	FYVE-RING finger protein SAKURA

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11871	RFFL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RFFL	RGD	RGD:727916
Bos taurus	RFFL	VGNC	VGNC:57149
Felis catus	RFFL	VGNC	VGNC:97603
Mus musculus	RFFL	MGD	MGI:1914588
Others	RFFL	NCBI