FAT3 - FAT atypical cadherin 3 Gene

Also Known as hFat3; CDHF15; CDHR10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 120114

About FAT3

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:92,224,818-92,896,473 (from NCBI)

This gene has 6 transcripts (splice variants), 317 orthologues, 6 paralogues and is associated with 124 phenotypes. Biased expression in brain (RPKM 1.5), prostate (RPKM 0.4) and 7 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Predicted to be located in dendrite and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

FAT3 Products (3)

mRNA Protein Name
NM_001008781.3 NP_001008781.2 protocadherin Fat 3 isoform 2 precursor
NM_001367949.2 NP_001354878.1 protocadherin Fat 3 isoform 1 precursor
NM_001378141.1 NP_001365070.1 protocadherin Fat 3 isoform 3 precursor

FAT3 Protein Structure

Cadherin

Cadherin: Cadherin domain (163 - 256)

Cadherin

Cadherin: Cadherin domain (477 - 568)

Cadherin

Cadherin: Cadherin domain (733 - 822)

Cadherin

Cadherin: Cadherin domain (836 - 924)

Cadherin

Cadherin: Cadherin domain (941 - 1031)

Cadherin

Cadherin: Cadherin domain (1050 - 1139)

Cadherin

Cadherin: Cadherin domain (1157 - 1245)

Cadherin

Cadherin: Cadherin domain (1259 - 1348)

Cadherin

Cadherin: Cadherin domain (1465 - 1557)

Cadherin

Cadherin: Cadherin domain (1571 - 1662)

Cadherin

Cadherin: Cadherin domain (1676 - 1759)

Cadherin

Cadherin: Cadherin domain (1792 - 1872)

Cadherin

Cadherin: Cadherin domain (1987 - 2075)

Cadherin

Cadherin: Cadherin domain (2096 - 2178)

Cadherin

Cadherin: Cadherin domain (2191 - 2273)

Cadherin

Cadherin: Cadherin domain (2292 - 2384)

Cadherin

Cadherin: Cadherin domain (2401 - 2487)

Cadherin

Cadherin: Cadherin domain (2501 - 2590)

Cadherin

Cadherin: Cadherin domain (2605 - 2699)

Cadherin

Cadherin: Cadherin domain (2822 - 2915)

Cadherin

Cadherin: Cadherin domain (2929 - 3007)

Cadherin

Cadherin: Cadherin domain (3034 - 3110)

Cadherin

Cadherin: Cadherin domain (3137 - 3227)

Cadherin

Cadherin: Cadherin domain (3241 - 3331)

Cadherin

Cadherin: Cadherin domain (3346 - 3436)

Cadherin

Cadherin: Cadherin domain (3451 - 3541)

Laminin_G_2

Laminin_G_2: Laminin G domain (3865 - 3993)

EGF_CA

EGF_CA: Calcium-binding EGF domain (4098 - 4129)

  • 0
  • 800
  • 1600
  • 2400
  • 3200
  • 4000
  • 4589 a.a.
Protein Preferred Names Protein Names

protocadherin Fat 3

  • FAT tumor suppressor homolog 3

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 45

  • SCA45

  • Spinocerebellar Ataxia Type 45
Classic Pulmonary Blastoma

  • Biphasic Pulmonary Blastoma
Van Maldergem Syndrome

  • Van Maldergem Wetzburger Verloes Syndrome

  • Cerebro-Facio-Articular Syndrome

  • Cerebro-Facio-Articular Syndrome Of Van Maldergem

  • Cerebrofacioarticular Syndrome

  • Cerebro Facio Articular Syndrome

  • Van Maldergem-Wetzburger-Verloes Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W009544 3-Hydroxytetradecanoic acid 98.0% Unkown
HY-RS04762 FAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FAT3 MGD MGI:2444314
Canis familiaris FAT3 VGNC VGNC:40744
Felis catus FAT3 VGNC VGNC:62159
Bos taurus FAT3 VGNC VGNC:28876
Rattus norvegicus FAT3 RGD RGD:620657
Others FAT3 NCBI