TRABD2A - TraB domain containing 2A Gene

Also Known as TIKI1; C2orf89

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 129293

About TRABD2A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:84,821,666-84,881,084 (from NCBI)

This gene has 10 transcripts (splice variants), 122 orthologues and 1 paralogue. Biased expression in colon (RPKM 11.1), ovary (RPKM 8.7) and 9 other tissues.

Summary

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in negative regulation of Wnt signaling pathway and proteolysis. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRABD2A Products (3)

mRNA	Protein	Name
NM_001080824.3	NP_001074293.1	metalloprotease TIKI1 isoform 2 precursor
NM_001277053.2	NP_001263982.1	metalloprotease TIKI1 isoform 1 precursor
NM_001307978.2	NP_001294907.1	metalloprotease TIKI1 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	22726442	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	22726442	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	22726442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	22726442	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	22726442	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in organelle membrane	IDA IDA: Inferred from direct assay	22726442	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22726442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
metalloprotease TIKI1	TRAB domain-containing protein 2A

Related Diseases

Diseases	Alias
Janus Kinase-3 Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14964	TRABD2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown