KLF14 - KLF transcription factor 14 Gene

Also Known as BTEB5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 136259

About KLF14

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,730,697-130,734,207 (from NCBI)

This gene has 1 transcript (splice variant), 707 orthologues and 22 paralogues.

Summary

This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta Receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

KLF14 Products (1)

mRNA Protein Name
NM_138693.4 NP_619638.2 Krueppel-like factor 14

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24759103 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24759103 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF14 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (211 - 238)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (242 - 265)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

Krueppel-like factor 14

  • BTE-binding protein 5

Related Diseases

Diseases Alias
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07335 KLF14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13609 SP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18223 Sp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22600 Klf14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29117 Klf14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLF14 VGNC VGNC:102624
Canis familiaris KLF14 VGNC VGNC:42433
Mus musculus KLF14 MGD MGI:3577024
Rattus norvegicus KLF14 RGD RGD:1306012
Macaca mulatta KLF14 VGNC VGNC:73890
Bos taurus KLF14 VGNC VGNC:106797
Others KLF14 NCBI