CTSZ - cathepsin Z Gene

Homo sapiens

Also known as CTSX

Gene ID: 1522 | Gene type: protein coding

About CTSZ

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,995,185-59,007,254 (from NCBI)

This gene has 32 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 146.3), appendix (RPKM 144.2) and 25 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as Cathepsin X and Cathepsin P. This gene is expressed ubiquitously in Cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

CTSZ Products(1)

mRNA	Protein	Name
NM_001336.4	NP_001327.2	cathepsin Z preproprotein

Protein Preferred Names

Protein Names

cathepsin Z

carboxypeptidase LB

Recombinant CTSZ Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7758	Cathepsin Z/CTSZ Protein, Human (HEK293, His)	Q9UBR2 (G24-V303)	≥95%

Related Diseases

Diseases

Alias

Cercarial Dermatitis

Swimmer'S Itch	Cutaneous Schistosomiasis
Sea Bather'S Eruption	Clam-Digger'S Itch
Rice-Paddy Itch	Sea Bather'S Itch
Sawah Itch	Schistosomal Cercarial Dermatitis

Mitochondrial Complex V Deficiency, Nuclear Type 5

Mitochondrial Complex V Deficiency	MC5DN5
Mitochondrial Complex V Deficiency, Atp5f1d Type	Mitochondrial Complex V Deficiency
Mitochondrial Complex 5 Deficiency Nuclear Type 5	Complex 5 Mitochondrial Respiratory Chain Deficiency
Atp Synthase Deficiency	Mitochondrial Complex V Deficiency, Nuclear Type 5
Complex V Deficiency

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03349	CTSZ Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CTSZ	VGNC	VGNC:61273
Macaca mulatta	CTSZ	VGNC	VGNC:71564
Mus musculus	CTSZ	MGD	MGI:1891190
Rattus norvegicus	CTSZ	RGD	RGD:708479
Canis familiaris	CTSZ	VGNC	VGNC:39717
Bos taurus	CTSZ	VGNC	VGNC:27820
Others	CTSZ	NCBI