CTSZ - cathepsin Z Gene

Also Known as CTSX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1522

About CTSZ

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,995,185-59,007,254 (from NCBI)

This gene has 32 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 146.3), appendix (RPKM 144.2) and 25 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as Cathepsin X and Cathepsin P. This gene is expressed ubiquitously in Cancer cell lines and primary tumors and, like Other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

CTSZ Products (1)

mRNA Protein Name
NM_001336.4 NP_001327.2 cathepsin Z preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
19433310 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of plasminogen activation IMP
IMP: Inferred from mutant phenotype
19433310 GOA
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
19433310 GOA
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
19433310 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
19433310 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
19433310 GOA
located in lysosome IDA
IDA: Inferred from direct assay
19433310 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cathepsin Z

  • carboxypeptidase LB

CTSZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTSZ Q9UBR2 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
CTSZ Q9UBR2 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
CTSZ Q9UBR2 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
CTSZ Q9UBR2 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra
CTSZ Q9UBR2 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
CTSZ Q9UBR2 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
CTSZ Q9UBR2 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CTSZ Q9UBR2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
CTSZ Q9UBR2 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
CTSZ Q9UBR2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CTSZ Q9UBR2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
CTSZ Q9UBR2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
CTSZ Q9UBR2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
CTSZ Q9UBR2 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRTAP5-9 Homo sapiens P26371
Y2H Array
31515488
Intra
CTSZ Q9UBR2 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
CTSZ Q9UBR2 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
CTSZ Q9UBR2 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
CTSZ Q9UBR2 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 PLSCR1 Homo sapiens O15162
Validated Y2H
25416956
Intra
CTSZ Q9UBR2 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
CTSZ Q9UBR2 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
CTSZ Q9UBR2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
CTSZ Q9UBR2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra
CTSZ Q9UBR2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
CTSZ Q9UBR2 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
CTSZ Q9UBR2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
CTSZ Q9UBR2 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
CTSZ Q9UBR2 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTSZ Proteins

Cat. No. Product Name Accession Purity
HY-P7758 Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution) Q9UBR2 (G24-V303) ≥ 95%, as determined by reducing SDS-PAGE.

CTSZ Antibodies

Cat. No. Product Name Application Reactivity
HY-P82637 Cathepsin Z Antibody (YA2382) WB, IHC-P Human, Mouse
HY-P82637A Cathepsin Z Antibody (YA2382)(PBS only) WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Cercarial Dermatitis

  • Swimmer'S Itch

  • Cutaneous Schistosomiasis

  • Sea Bather'S Eruption

  • Clam-Digger'S Itch

  • Rice-Paddy Itch

  • Sea Bather'S Itch

  • Sawah Itch

  • Schistosomal Cercarial Dermatitis
Mitochondrial Complex V Deficiency, Nuclear Type 5

  • Mitochondrial Complex V Deficiency

  • MC5DN5

  • Mitochondrial Complex V Deficiency, Atp5f1d Type

  • Mitochondrial Complex V Deficiency

  • Mitochondrial Complex 5 Deficiency Nuclear Type 5

  • Complex 5 Mitochondrial Respiratory Chain Deficiency

  • Atp Synthase Deficiency

  • Mitochondrial Complex V Deficiency, Nuclear Type 5

  • Complex V Deficiency
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03349 CTSZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17881 Ctsz Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24350 Ctsz Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CTSZ VGNC VGNC:61273
Macaca mulatta CTSZ VGNC VGNC:71564
Mus musculus CTSZ MGD MGI:1891190
Rattus norvegicus CTSZ RGD RGD:708479
Canis familiaris CTSZ VGNC VGNC:39717
Bos taurus CTSZ VGNC VGNC:27820
Others CTSZ NCBI