EDN2 - endothelin 2 Gene

Also Known as ET2; ET-2; PPET2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1907

About EDN2

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,478,775-41,484,683 (from NCBI)

This gene has 5 transcripts (splice variants), 267 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 7.3), esophagus (RPKM 3.9) and 5 other tissues.

Summary

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

EDN2 Products (2)

mRNA	Protein	Name
NM_001302269.2	NP_001289198.1	endothelin-2 isoform 2 preproprotein
NM_001956.5	NP_001947.1	endothelin-2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hormone activity	IDA IDA: Inferred from direct assay	2649896	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in artery smooth muscle contraction	IDA IDA: Inferred from direct assay	8982507	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	12207323	GOA
involved in macrophage activation	IDA IDA: Inferred from direct assay	12207323	GOA
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	12207323	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	9696419	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	1917960	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1917960	GOA
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	2649896	GOA
involved in positive regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	9696419	GOA
involved in positive regulation of prostaglandin-endoperoxide synthase activity	IMP IMP: Inferred from mutant phenotype	9492062	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	9492062	GOA
involved in regulation of systemic arterial blood pressure by endothelin	IDA IDA: Inferred from direct assay	2649896	GOA
involved in vasoconstriction	IDA IDA: Inferred from direct assay	2649896	GOA
involved in vein smooth muscle contraction	IDA IDA: Inferred from direct assay	8982507	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15691296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDN2 Protein Structure

Endothelin

0
100
178 a.a.

Protein Preferred Names	Protein Names
endothelin-2	preproendothelin 2

Related Diseases

Diseases	Alias
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Li-Fraumeni Syndrome 1	Lfs1
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04164	EDN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22152	Edn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EDN2	MGD	MGI:95284
Macaca mulatta	EDN2	VGNC	VGNC:72157
Rattus norvegicus	EDN2	RGD	RGD:2533
Canis familiaris	EDN2	VGNC	VGNC:40200
Bos taurus	EDN2	VGNC	VGNC:28328
Felis catus	EDN2	VGNC	VGNC:61727
Others	EDN2	NCBI