FCGRT - Fc gamma receptor and transporter Gene

Also Known as FCRN; FcgammaRn; alpha-chain

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2217

About FCGRT

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,512,661-49,526,428 (from NCBI)

This gene has 18 transcripts (splice variants), 352 orthologues and 22 paralogues. Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues.

Summary

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

FCGRT Products (6)

mRNA	Protein	Name
NM_001136019.3	NP_001129491.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001411064.1	NP_001397993.1	IgG receptor FcRn large subunit p51 isoform 2 precursor
NM_004107.5	NP_004098.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001136019.3	NP_001129491.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001411064.1	NP_001397993.1	IgG receptor FcRn large subunit p51 isoform 2 precursor
NM_004107.5	NP_004098.1	IgG receptor FcRn large subunit p51 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables IgG binding	IDA IDA: Inferred from direct assay	7964511	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCGRT Protein Structure

MHC_I

C1-set

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
IgG receptor FcRn large subunit p51	Fc fragment of IgG receptor and transporter

FCGRT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCGRT	P55899	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	FCGRT	P55899	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	FCGRT	P55899	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	FCGRT	P55899	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCGRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70601	FCRN-B2M Heterodimer Protein, Human (HEK293, C-His)	AAF72596 (A24-S297)&P61769 (I21-M119)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71664	FCGRT Protein, Human (HEK293, His)	P55899 (A24-S297)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72192	FCGRT Protein, Human (GST)	P55899 (A24-S297)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72368	FCRN-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)	AAF72596 (A24-S297)&P61769 (I21-M119)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73522	FCRN-B2M Heterodimer Protein, Human (HEK293, His)	P55899 (A24-S297)&P61769 (I21-M119)	≥ 95%, as determined by reducing SDS-PAGE.

FCGRT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84408	FCGRT Antibody (YA4105)	FC, ELISA	Human
HY-P84408A	FCGRT Antibody (YA4105)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 43	Hypoproteinemia, Hypercatabolic IMD43 Beta-2-Microglobulin Deficiency B2m Deficiency Hypercatabolic Hypoproteinemia
Persistent Fetal Circulation Syndrome	Persistent Fetal Circulation Fetal Circulation Persistent Pulmonary Hypertension Of The Newborn Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins Persistent Foetal Circulation Persistent Foetal Circulation Syndrome Pfc - [Persistent Fetal Circulation] Syndrome Pphn - [Persistent Pulmonary Hypertension Of The Newborn] Newborn Pulmonary Hypertension Primary Pulmonary Hypertension Of Newborn
Immunoglobulin G Deficiency	Igg Deficiency Igg Subclass Deficiency
Tetanus Neonatorum	Neonatal Tetanus NNT Trismus Neonatorum Newborn Trismus
Epidermolysis Bullosa Acquisita	Acquired Epidermolysis Bullosa Eb Acquisita Eba Eba - [Epidermolysis Bullosa Acquisita]
Neonatal Myasthenia Gravis	Myasthenia Gravis, Neonatal
Pemphigus
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Ankylosing Spondylitis 3
Transient Hypogammaglobulinemia
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Heart Block, Congenital	Congenital Heart Block Heart Block Congenital Congenital Atrioventricular Block
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Fetal Erythroblastosis	Erythroblastosis, Fetal Ef - Erythroblastosis Foetalis Erythroblastosis Fetalis Haemolytic Disease Due To Rhesus Isoimmunisation Rhesus Isoimmunisation Of The Newborn
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Brachydactyly, Type D	Brachydactyly Type D BDD Stub Thumb Brachydactyly D
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Demyelinating Polyneuropathy	Peripheral Demyelinating Neuropathy Demyelinating Peripheral Neuropathy
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04833	FCGRT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16869	Fcgrt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23310	Fcgrt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FCGRT	VGNC	VGNC:62209
Rattus norvegicus	FCGRT	RGD	RGD:61811
Canis familiaris	FCGRT	VGNC	VGNC:40803
Mus musculus	FCGRT	MGD	MGI:103017
Bos taurus	FCGRT	VGNC	VGNC:28934
Others	FCGRT	NCBI