FDPS - farnesyl diphosphate synthase Gene

Also Known as FPS; FPPS; POROK9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2224

About FDPS

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,308,866-155,320,665 (from NCBI)

This gene has 21 transcripts (splice variants), 229 orthologues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 72.6), duodenum (RPKM 62.1) and 25 other tissues.

Summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in Cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

FDPS Products (7)

mRNA	Protein	Name
NM_001135821.2	NP_001129293.1	farnesyl pyrophosphate synthase isoform a
NM_001135822.2	NP_001129294.1	farnesyl pyrophosphate synthase isoform b
NM_001242824.2	NP_001229753.1	farnesyl pyrophosphate synthase isoform b
NM_001242825.2	NP_001229754.1	farnesyl pyrophosphate synthase isoform c
NM_001378424.1	NP_001365353.1	farnesyl pyrophosphate synthase isoform b
NM_001378425.1	NP_001365354.1	farnesyl pyrophosphate synthase isoform b
NM_002004.4	NP_001995.1	farnesyl pyrophosphate synthase isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	17198737	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17198737	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	17198737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FDPS Protein Structure

polyprenyl_synt

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
farnesyl pyrophosphate synthase	(2E,6E)-farnesyl diphosphate synthase

FDPS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	FDPS	P14324	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	FDPS	P14324	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FDPS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75197	FDPS Protein, Human (His)	P14324-2/NP_001129294.1 (M1-K353)	≥ 95%, as determined by Bis-Tris PAGE.

FDPS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83072	FDPS Antibody (YA2817)	WB, IHC-P	Human, Hamster
HY-P83072A	FDPS Antibody (YA2817)(PBS only)	WB, IHC-P	Human, Hamster

Related Diseases

Diseases	Alias
Porokeratosis 9, Multiple Types	POROK9
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1
Punctate Porokeratosis	Porokeratosis, Punctate Keratoderma, Palmoplantar, Punctate Type Ii
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Linear Porokeratosis	Congenital Facial Linear Porokeratosis Porokeratosis, Linear
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 2c CMS2C Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Ischemic Bone Disease
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Bone Resorption Disease	Bone Resorption
Bone Remodeling Disease
Trypanosomiasis
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106950A	Fosfructose trisodium		98.0%	Unkown
HY-148077	Phosphoglycolohydroxamic acid	Inhibitor	98.0%	Unkown
HY-B0631S	Alendronic acid-d6		98.0%	Unkown
HY-RS04853	FDPS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17189	Fdps Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23640	Fdps Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FDPS	RGD	RGD:68953
Mus musculus	FDPS	MGD	MGI:104888
Macaca mulatta	FDPS	VGNC	VGNC:106366
Canis familiaris	FDPS	VGNC	VGNC:40812
Others	FDPS	NCBI