TMCC1 - transmembrane and coiled-coil domain family 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23023

About TMCC1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:129,647,792-129,893,711 (from NCBI)

This gene has 17 transcripts (splice variants), 299 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 4.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC1 Products (16)

mRNA Protein Name
NM_001017395.5 NP_001017395.2 transmembrane and coiled-coil domains protein 1 isoform a
NM_001128224.3 NP_001121696.1 transmembrane and coiled-coil domains protein 1 isoform c
NM_001349263.2 NP_001336192.1 transmembrane and coiled-coil domains protein 1 isoform a
NM_001349264.2 NP_001336193.1 transmembrane and coiled-coil domains protein 1 isoform a
NM_001349265.2 NP_001336194.1 transmembrane and coiled-coil domains protein 1 isoform a
NM_001349266.2 NP_001336195.1 transmembrane and coiled-coil domains protein 1 isoform a
NM_001349268.2 NP_001336197.1 transmembrane and coiled-coil domains protein 1 isoform a
NM_001349269.2 NP_001336198.1 transmembrane and coiled-coil domains protein 1 isoform c
NM_001349270.2 NP_001336199.1 transmembrane and coiled-coil domains protein 1 isoform c
NM_001349271.2 NP_001336200.1 transmembrane and coiled-coil domains protein 1 isoform d
NM_001349272.1 NP_001336201.1 transmembrane and coiled-coil domains protein 1 isoform e
NM_001349273.2 NP_001336202.1 transmembrane and coiled-coil domains protein 1 isoform f
NM_001349274.2 NP_001336203.1 transmembrane and coiled-coil domains protein 1 isoform g
NM_001349275.2 NP_001336204.1 transmembrane and coiled-coil domains protein 1 isoform h
NM_001349276.2 NP_001336205.1 transmembrane and coiled-coil domains protein 1 isoform h
NM_015008.5 NP_055823.1 transmembrane and coiled-coil domains protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
24454821 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24454821 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
24454821 GOA
involved in endosomal transport IDA
IDA: Inferred from direct assay
30220460 GOA
involved in endosome fission IDA
IDA: Inferred from direct assay
30220460 GOA
involved in endosome membrane tubulation IDA
IDA: Inferred from direct assay
30220460 GOA
involved in membrane fission IDA
IDA: Inferred from direct assay
30220460 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IMP
IMP: Inferred from mutant phenotype
24454821 GOA
located in endoplasmic reticulum-endosome membrane contact site IDA
IDA: Inferred from direct assay
30220460 GOA
located in rough endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
24454821 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMCC1 Protein Structure

Tmemb_cc2

Tmemb_cc2: Predicted transmembrane and coiled-coil 2 protein (229 - 640)

  • 0
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  • 600
  • 653 a.a.
Protein Preferred Names Protein Names

transmembrane and coiled-coil domains protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14629 TMCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMCC1 VGNC VGNC:66239
Bos taurus TMCC1 VGNC VGNC:35925
Mus musculus TMCC1 MGD MGI:2442368
Macaca mulatta TMCC1 VGNC VGNC:79776
Rattus norvegicus TMCC1 RGD RGD:1311909
Canis familiaris TMCC1 VGNC VGNC:47428
Others TMCC1 NCBI