ADGRL2 - adhesion G protein-coupled receptor L2 Gene

Also Known as CL2; LEC1; CIRL2; LPHH1; LPHN2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23266

About ADGRL2

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:81,306,132-81,993,932 (from NCBI)

This gene has 42 transcripts (splice variants), 199 orthologues and 42 paralogues. Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues.

Summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ADGRL2 Products (21)

mRNA Protein Name
NM_001297704.3 NP_001284633.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001297705.3 NP_001284634.1 adhesion G protein-coupled receptor L2 isoform 2 precursor
NM_001297706.3 NP_001284635.1 adhesion G protein-coupled receptor L2 isoform 3 precursor
NM_001330645.3 NP_001317574.1 adhesion G protein-coupled receptor L2 isoform 4 precursor
NM_001350698.2 NP_001337627.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001350699.2 NP_001337628.1 adhesion G protein-coupled receptor L2 isoform 6 precursor
NM_001366002.2 NP_001352931.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001366003.2 NP_001352932.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001366004.2 NP_001352933.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001366005.2 NP_001352934.1 adhesion G protein-coupled receptor L2 isoform 7 precursor
NM_001366006.2 NP_001352935.1 adhesion G protein-coupled receptor L2 isoform 7 precursor
NM_001366007.2 NP_001352936.1 adhesion G protein-coupled receptor L2 isoform 8 precursor
NM_001366008.2 NP_001352937.1 adhesion G protein-coupled receptor L2 isoform 9 precursor
NM_001366009.2 NP_001352938.1 adhesion G protein-coupled receptor L2 isoform 10 precursor
NM_001393349.1 NP_001380278.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001393350.1 NP_001380279.1 adhesion G protein-coupled receptor L2 isoform 4 precursor
NM_001393351.1 NP_001380280.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001393352.1 NP_001380281.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001393353.1 NP_001380282.1 adhesion G protein-coupled receptor L2 isoform 11 precursor
NM_001393354.1 NP_001380283.1 adhesion G protein-coupled receptor L2 isoform 6 precursor
NM_012302.5 NP_036434.1 adhesion G protein-coupled receptor L2 isoform 1 precursor

ADGRL2 Protein Structure

Gal_Lectin

Gal_Lectin: Galactose binding lectin domain (49 - 129)

OLF

OLF: Olfactomedin-like domain (140 - 393)

HRM

HRM: Hormone receptor domain (467 - 523)

(531 - 761)

GPS

GPS: GPCR proteolysis site, GPS, motif (785 - 831)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (846 - 1095)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1115 - 1474)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1474 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor L2

  • calcium-independent alpha-latrotoxin receptor 2

Related Diseases

Diseases Alias
Eosinophilic Meningitis

  • Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00362 ADGRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADGRL2 VGNC VGNC:69632
Canis familiaris ADGRL2 VGNC VGNC:37651
Rattus norvegicus ADGRL2 RGD RGD:620835
Felis catus ADGRL2 VGNC VGNC:59639
Mus musculus ADGRL2 MGD MGI:2139714
Bos taurus ADGRL2 VGNC VGNC:53846
Others ADGRL2 NCBI