TTC28 - tetratricopeptide repeat domain 28 Gene

Also Known as TPRBK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23331

About TTC28

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:27,978,014-28,679,840 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.6) and 24 other tissues.

Summary

Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody. [provided by Alliance of Genome Resources, Apr 2022]

TTC28 Products (4)

mRNA Protein Name
NM_001145418.2 NP_001138890.1 tetratricopeptide repeat protein 28 isoform 1
NM_001393403.1 NP_001380332.1 tetratricopeptide repeat protein 28 isoform 2
NM_001393404.1 NP_001380333.1 tetratricopeptide repeat protein 28 isoform 3
NM_001393405.1 NP_001380334.1 tetratricopeptide repeat protein 28 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
23036704 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23036704 GOA
Cellular Component GO Annotation Evidence References Source
located in midbody IDA
IDA: Inferred from direct assay
23036704 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC28 Protein Structure

TPR_11

TPR_11: TPR repeat (63 - 123)

TPR_2

TPR_2: Tetratricopeptide repeat (126 - 158)

TPR_7

TPR_7: Tetratricopeptide repeat (276 - 309)

TPR_12

TPR_12: Tetratricopeptide repeat (315 - 385)

TPR_1

TPR_1: Tetratricopeptide repeat (394 - 425)

TPR_12

TPR_12: Tetratricopeptide repeat (477 - 543)

TPR_12

TPR_12: Tetratricopeptide repeat (553 - 625)

TPR_2

TPR_2: Tetratricopeptide repeat (635 - 666)

TPR_1

TPR_1: Tetratricopeptide repeat (674 - 696)

TPR_10

TPR_10: Tetratricopeptide repeat (754 - 787)

TPR_1

TPR_1: Tetratricopeptide repeat (795 - 819)

TPR_12

TPR_12: Tetratricopeptide repeat (833 - 908)

TPR_12

TPR_12: Tetratricopeptide repeat (956 - 1021)

TPR_12

TPR_12: Tetratricopeptide repeat (1037 - 1109)

CHAT

CHAT: CHAT domain (1391 - 1713)

  • 0
  • 400
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  • 1600
  • 2000
  • 2481 a.a.
Protein Preferred Names Protein Names

tetratricopeptide repeat protein 28

  • TPR repeat protein 28

Related Diseases

Diseases Alias
Ankyloglossia With Or Without Tooth Anomalies

  • Ankyloglossia

  • ANKG

  • 'Tongue-Tie'

  • Tongue-Tie

  • Tongue Tie

  • Aberrant Insertion Of Labial Frenulum

  • Aberrant Insertion Of Frenum Of Tongue

  • Short Frenulum Linguae

  • Short Frenulum Of Tongue
Cleft Soft Palate

  • Cleft Velum

  • Cleft Velum Palatinum

  • Soft Cleft Palate

  • Soft Palate Perforation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15206 TTC28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TTC28 VGNC VGNC:66664
Rattus norvegicus TTC28 RGD RGD:1594541
Macaca mulatta TTC28 VGNC VGNC:79785
Bos taurus TTC28 VGNC VGNC:36467
Mus musculus TTC28 MGD MGI:2140873
Canis familiaris TTC28 VGNC VGNC:47948
Others TTC28 NCBI