RPL13A - ribosomal protein L13a Gene

Also Known as L13A; TSTA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23521

About RPL13A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,487,608-49,492,308 (from NCBI)

This gene has 22 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 1600.3), lymph node (RPKM 1020.4) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RPL13A Products (2)

mRNA Protein Name
NM_001270491.2 NP_001257420.1 60S ribosomal protein L13a isoform 2
NM_012423.4 NP_036555.1 60S ribosomal protein L13a isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
15479637 GOA
involved in negative regulation of formation of translation preinitiation complex IDA
IDA: Inferred from direct assay
17218275 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
14567916 GOA
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
15479637 GOA
Cellular Component GO Annotation Evidence References Source
part of GAIT complex IDA
IDA: Inferred from direct assay
15479637 GOA
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
15479637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL13A Protein Structure

Ribosomal_L13

Ribosomal_L13: Ribosomal protein L13 (7 - 120)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L13a

  • 23 kDa highly basic protein

Related Diseases

Diseases Alias
Spermatogenic Failure 2

  • SPGF2

  • Aspermiogenesis Factor

  • Asg
Spermatogenic Failure 1

  • Oligosynaptic Infertility

  • SPGF1

  • Oligochiasmatic Infertility

  • Oligochiasmic Infertility
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12165 RPL13A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RPL13A VGNC VGNC:103747
Rattus norvegicus RPL13A RGD RGD:628697
Canis familiaris RPL13A VGNC VGNC:103701
Mus musculus RPL13A MGD MGI:1351455
Bos taurus RPL13A VGNC VGNC:53040
Others RPL13A NCBI