Vax2 - ventral anterior homeobox 2 Gene

Also Known as Dres93

Species: Mus musculus

Gene Type: protein coding

Gene ID: 24113

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in forebrain development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within axonogenesis; dorsal/ventral axis specification; and eye development. Located in cytoplasm and nucleus. Is expressed in central nervous system; eye; and limb. Orthologous to human VAX2 (ventral anterior homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Vax2 Products (1)

mRNA	Protein	Name
NM_011912.4	NP_036042.1	ventral anterior homeobox 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15905411	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15905411	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	15905411	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	11830579	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	15905411	MGI
acts upstream of or within dorsal/ventral axis specification	IMP IMP: Inferred from mutant phenotype	11830578	MGI
acts upstream of or within embryonic eye morphogenesis	IDA IDA: Inferred from direct assay	10595508	MGI
acts upstream of or within embryonic eye morphogenesis	IMP IMP: Inferred from mutant phenotype	11830579	MGI
involved in forebrain development	IMP IMP: Inferred from mutant phenotype	21856776	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15905411	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15905411	MGI
acts upstream of or within retina development in camera-type eye	IDA IDA: Inferred from direct assay	10595508	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17043310	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17043310	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ventral anterior homeobox 2	ventral anterior homeobox containing gene 2 ventral retina homeodomain protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15616	VAX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vax2	NCBI	NCBI:25806