Ralgapa2 - Ral GTPase activating protein, alpha subunit 2 (catalytic) Gene

Also Known as P220; RGC2; AS250; pp250; A230067G21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 241694

Summary

Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory cortex mantle layer; and olfactory epithelium. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Ralgapa2 Products (4)

mRNA Protein Name
NM_001033348.4 NP_001028520.2 ral GTPase-activating protein subunit alpha-2 isoform 1
NM_001408200.1 NP_001395129.1 ral GTPase-activating protein subunit alpha-2 isoform 2
NM_001408201.1 NP_001395130.1 ral GTPase-activating protein subunit alpha-2 isoform 3
NM_001408202.1 NP_001395131.1 ral GTPase-activating protein subunit alpha-2 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IGI
IGI: Inferred from genetic interaction
21148297 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25220458 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Ral protein signal transduction IMP
IMP: Inferred from mutant phenotype
21148297 MGI
acts upstream of or within activation of GTPase activity IGI
IGI: Inferred from genetic interaction
21148297 MGI
acts upstream of or within regulation of exocyst localization IMP
IMP: Inferred from mutant phenotype
21148297 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
21148297 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ral GTPase-activating protein subunit alpha-2

  • 250 kDa substrate of Akt

  • ral GTPase-activating protein alpha subunit 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11631 RALGAPA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ralgapa2 NCBI NCBI:57186