2. Gene
  3. Mcph1 - microcephaly, primary autosomal recessive 1 Gene

Mcph1 - microcephaly, primary autosomal recessive 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MCT; BRIT1; 5430437K10Rik; D030046N04Rik; Tg(HLA-A2.1)1Enge

Gene ID: 244329 | Gene type: protein coding

About Mcph1

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including establishment of mitotic spindle orientation; neuronal stem cell population maintenance; and protein localization to centrosome. Predicted to be located in cytoplasm and Cytoskeleton. Is expressed in brain. Used to study microcephaly. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Orthologous to human MCPH1 (microcephalin 1). [provided by Alliance of Genome Resources, Apr 2022]

Mcph1 Products(1)

mRNA Protein Name
NM_173189.3 NP_775281.2 microcephalin
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
23516444 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
21947081 MGI
acts upstream of or within establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
21947081 MGI
acts upstream of or within neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
21947081 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
21947081 MGI
acts upstream of or within regulation of centrosome cycle IMP
IMP: Inferred from mutant phenotype
21947081 MGI
acts upstream of or within regulation of chromosome condensation IMP
IMP: Inferred from mutant phenotype
20169082 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
21737879 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21737879 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23516444 MGI
acts upstream of or within regulation of kinase activity IMP
IMP: Inferred from mutant phenotype
21737879 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microcephalin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08247 MCPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcph1 NCBI NCBI:79648