Adcy6 - adenylate cyclase 6 Gene

Rattus norvegicus

Also known as AC6; ACVI; ADCYB

Gene ID: 25289 | Gene type: protein coding

About Adcy6

Summary

Enables several functions, including SNARE binding activity; calcium- and calmodulin-responsive Adenylate Cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Located in endosome; membrane raft; and microvillus membrane. Colocalizes with sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (Adenylate Cyclase 6). [provided by Alliance of Genome Resources, Apr 2022]

Adcy6 Products(2)

mRNA	Protein	Name
NM_001270785.1	NP_001257714.1	adenylate cyclase type 6 isoform 1
NM_012821.5	NP_036953.5	adenylate cyclase type 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	21986494	RGD
enables adenylate cyclase activity	IDA IDA: Inferred from direct assay	11738086	RGD
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA IDA: Inferred from direct assay	10894801	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15385642	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12748066	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP biosynthetic process	IDA IDA: Inferred from direct assay	10894801	RGD
involved in cAMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	10866989	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	16166080	RGD
involved in maintenance of protein location in plasma membrane	IMP IMP: Inferred from mutant phenotype	21986494	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	21986494	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	17010343	RGD
located in membrane	IDA IDA: Inferred from direct assay	15385642	RGD
located in microvillus membrane	IDA IDA: Inferred from direct assay	10866989	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21986494	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15961389	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylate cyclase type 6

ATP pyrophosphate-lyase 6	adenylate cyclase type VI
adenylyl cyclase 6	ca(2+)-inhibitable adenylyl cyclase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00332	ADCY6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy6	NCBI	NCBI:112

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