STXBP4 - syntaxin binding protein 4 Gene

Also Known as Synip

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 252983

About STXBP4

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,968,765-55,213,273 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 1.4), thyroid (RPKM 1.4) and 25 other tissues.

Summary

Enables syntaxin binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

STXBP4 Products (4)

mRNA Protein Name
NM_001398481.1 NP_001385410.1 syntaxin-binding protein 4 isoform 2
NM_001398482.1 NP_001385411.1 syntaxin-binding protein 4 isoform 3
NM_001398483.1 NP_001385412.1 syntaxin-binding protein 4 isoform 4
NM_178509.6 NP_848604.3 syntaxin-binding protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19451233 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
12855681 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
19451233 GOA
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
19451233 GOA
involved in positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
19451233 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
19451233 GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
12855681 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STXBP4 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (27 - 97)

WW

WW: WW domain (498 - 527)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

syntaxin-binding protein 4

  • STX4-interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13992 STXBP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STXBP4 RGD RGD:1307903
Felis catus STXBP4 VGNC VGNC:99466
Bos taurus STXBP4 VGNC VGNC:106959
Mus musculus STXBP4 MGD MGI:1342296
Macaca mulatta STXBP4 VGNC VGNC:78173
Canis familiaris STXBP4 VGNC VGNC:46962