Abcc9 - ATP binding cassette subfamily C member 9 Gene

Rattus norvegicus

Also known as Sur2

Gene ID: 25560 | Gene type: protein coding

About Abcc9

Summary

Enables several functions, including identical protein binding activity; sulfonylurea receptor activity; and syntaxin binding activity. Contributes to cation channel activity. Involved in potassium ion import across plasma membrane; response to ATP; and response to xenobiotic stimulus. Located in T-tubule; acrosomal vesicle; and mitochondrion. Part of inward rectifying Potassium Channel. Biomarker of Parkinsonism; hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1O; familial atrial fibrillation; and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human ABCC9 (ATP binding cassette subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]

Abcc9 Products(1)

mRNA	Protein	Name
NM_013040.3	NP_037172.2	ATP-binding cassette sub-family C member 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	28842488	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	23078514	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	23253866	RGD
enables potassium channel activator activity	IMP IMP: Inferred from mutant phenotype	26621776	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	8630239	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19491242	RGD
enables sulfonylurea receptor activity	IDA IDA: Inferred from direct assay	8630239	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	15339904	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in inorganic cation transmembrane transport	IGI IGI: Inferred from genetic interaction	28842488	RGD
involved in monoatomic cation transmembrane transport	IMP IMP: Inferred from mutant phenotype	26621776	RGD
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	8630239	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10347249	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	11567030	RGD
involved in response to ATP	IGI IGI: Inferred from genetic interaction	26621776	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15964031	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15647111	RGD
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	21328565	RGD
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	8630239	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family C member 9

ATP-binding cassette transporter sub-family C member 9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ATP-binding cassette, sub-family C, member 9-like	ATP-binding cassette, subfamily C (CFTR/MRP), member 9
Sulfonylurea receptor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00067	ABCC9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22364	Abcc9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc9	NCBI	NCBI:10060

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