Nkx2-1 - NK2 homeobox 1 Gene

Rattus norvegicus

Also known as TTF1; Titf1

Gene ID: 25628 | Gene type: protein coding

About Nkx2-1

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; TBP-class protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to Leptin stimulus; embryonic lung development; and hyperosmotic salinity response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-1 Products(2)

mRNA	Protein	Name
NM_013093.1	NP_037225.1	homeobox protein Nkx-2.1
NM_013093.1	NP_037225.1	homeobox protein Nkx-2.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1976511	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15173172	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8625983	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	9425125	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1976511	RGD
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	9425125	RGD
enables core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	9425125	RGD
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	9425125	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9425125	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17729273	RGD
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9425125	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	11438542	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to leptin stimulus	IEP IEP: Inferred from expression pattern	23894445	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	22356123	RGD
involved in development of primary female sexual characteristics	IEP IEP: Inferred from expression pattern	11161473	RGD
involved in embryonic lung development	IEP IEP: Inferred from expression pattern	23894445	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	16970909	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12441357	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9425125	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8625983	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15173172	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18395010	RGD
involved in regulation of blood volume by renin-angiotensin	IDA IDA: Inferred from direct assay	12730191	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15893608	RGD
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	16627577	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	12441357	RGD
located in nucleus	IMP IMP: Inferred from mutant phenotype	9425125	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-2.1

TTF-1	thyroid nuclear factor 1
thyroid transcription factor 1 TTF-1 NK-2	thyroid-specific transcription factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-RS09327	NKX2-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx2-1	NCBI	NCBI:7080

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