G6PC1 - G6pc1 glucose-6-phosphatase catalytic subunit 1 Gene

Rattus norvegicus

Also known as G6pc; Psme3; G6Pase

Gene ID: 25634 | Gene type: protein coding

About G6PC1

Summary

Enables glucose-6-phosphatase activity. Involved in several processes, including gluconeogenesis; phosphorylated carbohydrate dephosphorylation; and response to resveratrol. Located in intracellular membrane-bounded organelle. Used to study type 2 diabetes mellitus. Biomarker of fatty liver disease. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

G6PC1 Products(1)

mRNA	Protein	Name
NM_013098.2	NP_037230.2	glucose-6-phosphatase catalytic subunit 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucose-6-phosphatase activity	IDA IDA: Inferred from direct assay	4303362	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	19579180	RGD
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	4303362	RGD
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	4303362	RGD
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	9813078	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	26883980	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	14988444	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	27366200	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25943649	RGD
involved in response to resveratrol	IEP IEP: Inferred from expression pattern	27366200	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glucose-6-phosphatase catalytic subunit 1

G-6-Pase	glucose-6-phosphatase, catalytic subunit
proteasome activator subunit 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05191	G6PC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	G6PC1	NCBI	NCBI:2538

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