Khk - ketohexokinase Gene

Also Known as KETHPRO

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25659

Summary

Enables Ketohexokinase activity. Involved in several processes, including response to hexose; response to insulin; and response to sucrose. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (Ketohexokinase). [provided by Alliance of Genome Resources, Apr 2022]

Khk Products (1)

mRNA Protein Name
NM_031855.3 NP_114061.1 ketohexokinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ketohexokinase activity IDA
IDA: Inferred from direct assay
8471037 RGD
Biological Process GO Annotation Evidence References Source
involved in fructose metabolic process IDA
IDA: Inferred from direct assay
8471037 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
18346472 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
5570341 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
6088170 RGD
involved in response to sucrose IDA
IDA: Inferred from direct assay
6147160 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
12721403 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ketohexokinase

  • hepatic fructokinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17613 Evocalcet Activator 99.28% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9925 Brodalumab Inhibitor 99.18% Unkown
HY-P9923 Benralizumab 99.46% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00461 PF-06835919 Inhibitor 99.53% Phase 2
HY-149987 LY3522348 Inhibitor 98.30% Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99955 Rocatinlimab 99.95% Phase 3
HY-P990610 KHK-2898 Inhibitor 97.16% Phase 1
HY-P990609 KHK-2866 98.23% Phase 1
HY-P991282 KHK2823 Inhibitor / Phase 1
HY-P991536 KHK6640 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9923A Benralizumab (anti-IL5RA) Inducer 99.60% Unkown
HY-12841A KHK-IN-1 hydrochloride Inhibitor 98.95% Unkown
HY-103478 KHK-IN-2 Inhibitor 99.05% Unkown
HY-12841 KHK-IN-1 Inhibitor 99.00% Unkown
HY-159123 KHK-6 Inhibitor / Unkown
HY-180921 GS-1291269 Inhibitor / Unkown
HY-RS07240 KHK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149605 KHK-IN-4 Inhibitor / Unkown
HY-162982 KHK-IN-6 / Unkown
HY-163886 KHK-IN-5 Inhibitor / Unkown
HY-172610 KHK-IN-7 Inhibitor / Unkown
HY-17613S Evocalcet-d4 Activator / Unkown
HY-208737 KHK-IN-8 Inhibitor / Unkown
HY-RS17728 Khk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24193 Khk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991918 KHK2840 Agonist / Unkown
HY-P992004 KHK2805 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Khk NCBI NCBI:3795