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製品番号: HY-149605

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KHK-IN-4

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research.

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CAS 番号: 3034829-40-5
分子式: C₁₈H₂₄F₂N₄O₂
分子量:366.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KHK-IN-4 構造式

CAS 番号: 3034829-40-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research^[1].

Ketohexokinase アイソフォーム固有の製品をすべて表示 :

KHK-A
KHK-C

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	>150 μM Compound: ent-14	Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay	[PMID: 37766386]
HepG2	IC₅₀	>150 μM Compound: ent-14	Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis	[PMID: 37766386]
HepG2	IC₅₀	>150 μM Compound: ent-14	Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay	[PMID: 37766386]
HepG2	IC₅₀	196 nM Compound: ent-14	Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis	[PMID: 37766386]

化学情報

CAS 番号 3034829-40-5
分子量 366.41
分子式 C₁₈H₂₄F₂N₄O₂
SMILES

C[C@H]1CCN1C2=NC(N3CC[C@@H](C3)CCC(O)=O)=C4C(C(F)(CC4)F)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Guodong Zhu, et al. Discovery of a Novel Ketohexokinase Inhibitor with Improved Drug Distribution in Target Tissue for the Treatment of Fructose Metabolic Disease. J Med Chem. 2023 Oct 12;66(19):13501-13515. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
化学情報
純度とドキュメンテーション
参考文献

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KHK-IN-4

Ketohexokinase アイソフォーム固有の製品をすべて表示