KHK-IN-4
KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research.
For research use only. We do not sell to patients.
- CAS No.: 3034829-40-5
- Formula: C18H24F2N4O2
- Molecular Weight:366.41
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
>150 μM
Compound: ent-14
|
Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay
Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay
|
[PMID: 37766386] |
| HepG2 | IC50 |
>150 μM
Compound: ent-14
|
Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis
Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis
|
[PMID: 37766386] |
| HepG2 | IC50 |
>150 μM
Compound: ent-14
|
Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay
Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay
|
[PMID: 37766386] |
| HepG2 | IC50 |
196 nM
Compound: ent-14
|
Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis
Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis
|
[PMID: 37766386] |
Chemical Information
-
CAS No. 3034829-40-5
-
Molecular Weight 366.41
-
Formula C18H24F2N4O2
-
SMILES
C[C@H]1CCN1C2=NC(N3CC[C@@H](C3)CCC(O)=O)=C4C(C(F)(CC4)F)=N2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz