CACNA1B - Cacna1b calcium voltage-gated channel subunit alpha1 B Gene

Also Known as BIII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 257648

Summary

Enables high voltage-gated Calcium Channel activity; protein Phosphatase 2A binding activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including positive regulation of neurotransmitter secretion; response to ethanol; and response to testosterone. Located in several cellular components, including axon terminus; dendritic shaft; and neuronal cell body. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]

CACNA1B Products (3)

mRNA Protein Name
NM_001195199.2 NP_001182128.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 1
NM_001413253.1 NP_001400182.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 3
NM_147141.3 NP_671482.1 voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
18701069 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9830048 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
15728831 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
1317580 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
10864934 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels EXP
EXP: Inferred from Experiment
7832825 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
7832825 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
15548655 RGD
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
10864934 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
15987667 RGD
involved in regulation of calcium-dependent activation of synaptic vesicle fusion EXP
EXP: Inferred from Experiment
7832825 RGD
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
7832825 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16860782 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
16704976 RGD
involved in response to testosterone IMP
IMP: Inferred from mutant phenotype
15987667 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
7832825 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
7832825 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
16736476 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
11353727 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
7832825 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
7832825 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11353727 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17068255 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent N-type calcium channel subunit alpha-1B

  • brain calcium channel III

  • calcium channel, L type, alpha-1 polypeptide

  • calcium channel, voltage-dependent, N type, alpha 1B subunit

  • voltage gated N-type calcium channel Ca(v)2.2

  • voltage-dependent N-type calcium channel subunit alpha-1B-like

  • voltage-g

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01792 CACNA1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CACNA1B NCBI NCBI:774