Myo7a - myosin VIIA Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 266714

Summary

Enables several functions, including adenyl ribonucleotide binding activity; Calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in cytoplasm; microvillus; and upper tip-link density. Part of Myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (Myosin VIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo7a Products (3)

mRNA Protein Name
NM_001414743.1 NP_001401672.1 unconventional myosin-VIIa isoform 1
NM_153473.2 NP_703203.1 unconventional myosin-VIIa isoform 2
NM_153473.1 NP_703203.1 unconventional myosin-VIIa

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
12466270 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
12466270 RGD
enables actin binding IDA
IDA: Inferred from direct assay
12466270 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
12466270 RGD
enables cytoskeletal motor activity IDA
IDA: Inferred from direct assay
12466270 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12466270 RGD
enables microfilament motor activity IDA
IDA: Inferred from direct assay
12466270 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23329832 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12466270 RGD
Biological Process GO Annotation Evidence References Source
involved in actin filament-based movement IDA
IDA: Inferred from direct assay
12466270 RGD
Cellular Component GO Annotation Evidence References Source
part of myosin VII complex IDA
IDA: Inferred from direct assay
12466270 RGD
part of myosin complex IDA
IDA: Inferred from direct assay
12466270 RGD
located in upper tip-link density IDA
IDA: Inferred from direct assay
21709241 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-VIIa

  • myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))

  • myosin-VIIa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08950 MYO7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo7a NCBI NCBI:4647