Myo7a - myosin VIIA Gene

Rattus norvegicus

Gene ID: 266714 | Gene type: protein coding

About Myo7a

Summary

Enables several functions, including adenyl ribonucleotide binding activity; Calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in cytoplasm; microvillus; and upper tip-link density. Part of Myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (Myosin VIIA). [provided by Alliance of Genome Resources, Apr 2022]

Myo7a Products(3)

mRNA	Protein	Name
NM_001414743.1	NP_001401672.1	unconventional myosin-VIIa isoform 1
NM_153473.2	NP_703203.1	unconventional myosin-VIIa isoform 2
NM_153473.1	NP_703203.1	unconventional myosin-VIIa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	12466270	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	12466270	RGD
enables actin binding	IDA IDA: Inferred from direct assay	12466270	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	12466270	RGD
enables cytoskeletal motor activity	IDA IDA: Inferred from direct assay	12466270	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12466270	RGD
enables microfilament motor activity	IDA IDA: Inferred from direct assay	12466270	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23329832	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12466270	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament-based movement	IDA IDA: Inferred from direct assay	12466270	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of myosin VII complex	IDA IDA: Inferred from direct assay	12466270	RGD
part of myosin complex	IDA IDA: Inferred from direct assay	12466270	RGD
located in upper tip-link density	IDA IDA: Inferred from direct assay	21709241	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

unconventional myosin-VIIa

myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))

myosin-VIIa

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08950	MYO7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo7a	NCBI	NCBI:4647

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